{"product_id":"biolegend-159406","title":"Biolegend, 159406, APC anti-mouse IL-13 Antibody, 100μg","description":"\u003cp\u003eMouse IL-13 was initially cloned from cDNA libraries of activated T cells and was designated as P600. IL-13 is an immunoregulatory cytokine secreted predominantly by activated Th2 cells, and it is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional properties with IL-4, and they share a common receptor subunit, the alpha subunit of the IL-4 receptor (IL-4Ra). IL-13 mediates its effects by interacting with a complex receptor system comprised of IL-4Ra and two IL-13 binding proteins, IL-13Ralpha1 and IL-13Ralpha2. Ligation of the IL-13 receptor complex results in signaling via the insulin receptor substrate (IRS)-1 and 2 and STAT-6 pathways. IL-13 has been implicated in inflammatory responses, such as airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-13\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC – Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2910327 (BioLegend Cat. No. 159405) AB_2910327 (BioLegend Cat. No. 159406)\u003cbr\u003e\nStructure: Cytokine\u003cbr\u003e\nDistribution: Th2 cells, basophils, mast cells, activated eosinophils and NK cells\u003cbr\u003e\nFunction: IL-13 modulates mouse monocytes\/macrophages and B cells. IL-13 induces an increase of MHC class II expression in mouse monocytes\/macrophages, and direct inhibition of inflammatory cytokines such as TNF-α and IL-1β.\u003cbr\u003e\nLigand\/Receptor: IL-4Rα, IL-13Rα1, and IL-13Rα2\u003cbr\u003e\nCell Type: Basophils, Eosinophils, Mast cells, NK cells, Th2\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Brown KD, et al. 1989. J Immunol. 142:679-87. McKenzie AN, et al. 1993. Proc Natl Acad Sci USA. 90:3735-9. McKenzie GJ, et al. 1999. J Exp Med. 189:1565-72.\u003cbr\u003e\nGene ID: 16163\u003cbr\u003e\nUniProt: View information about IL-13 on UniProt.org\u003cbr\u003e\nClone: W17010B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin 13\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866310201513,"sku":"159406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-159406","provider":"Iright","version":"1.0","type":"link"}