{"product_id":"biolegend-159603","title":"Biolegend, 159603, PE anti-mouse PD-1H (VISTA) Antibody, 25μg","description":"\u003cp\u003ePD-1H, also known as VISTA, is a 309 aa type I transmembrane protein, composed of seven exons. PD-1H has one Ig-V like domain, and its sequence is similar to the Ig-V domains of the members of CD28 and B7 families. PD-1H is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It has been proposed that PD-1H can be useful to modulate the host immune response to allogeneic transplants.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse VISTA protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone A17207I antibody is able to completely block the staining of clone MH5A antibody.\u003cbr\u003e\nProduct Citations: Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed\u003cbr\u003e\nRRID: AB_2876555 (BioLegend Cat. No. 159603) AB_2876555 (BioLegend Cat. No. 159604)\u003cbr\u003e\nStructure: Type I transmembrane protein, member of the CD28 family\u003cbr\u003e\nDistribution: Macrophages, dendritic cells, neutrophils, NK cells, naïve and activated T cells\u003cbr\u003e\nFunction: Negative regulation of immune response\u003cbr\u003e\nLigand\/Receptor: PSGL-1\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Neutrophils, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Inhibitory Molecules\u003cbr\u003e\nAntigen References: Flies DB, et al. 2011. J. Immunol. 187:1537. Wang Li, et al. 2011. J. Exp Med. 208:577.\u003cbr\u003e\nGene ID: 74048\u003cbr\u003e\nUniProt: View information about PD-1H on UniProt.org\u003cbr\u003e\nClone: A17207I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PD-1 homolog, Dies1, B7-H5\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866057789609,"sku":"159603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-159603","provider":"Iright","version":"1.0","type":"link"}