{"product_id":"biolegend-160407","title":"Biolegend, 160407, APC anti-mouse CD126 (IL-6Rα) Antibody, 25μg","description":"\u003cp\u003eCD126 (IL-6Rα) is an 80kD member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain\/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse IL-6R recombinant protein, 1-357 a.a.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone W18166A binds to IL-6 receptor alpha, inhibits IL-6\/IL-6 receptor interaction and mediated phosphorylation of signal transducer and activator of transcription 3 (STAT3). This clone does not cross-react with rat.\u003cbr\u003e\nRRID: AB_2894646 (BioLegend Cat. No. 160407) AB_2894646 (BioLegend Cat. No. 160408)\u003cbr\u003e\nStructure: Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD\u003cbr\u003e\nDistribution: T cells and activated B cells, monocytes, hepatocytes, plasma cells\u003cbr\u003e\nFunction: Stimulates T cells, B cells, hematopoietic precursor proliferation and differentiation\u003cbr\u003e\nLigand\/Receptor: IL-6\u003cbr\u003e\nCell Type: B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Taga T, et al. 1997. Annu Rev Immunol. 15:797-819. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London. Boulanger MJ, et al. 2003. Science. 300:2101-4\u003cbr\u003e\nGene ID: 16194\u003cbr\u003e\nUniProt: View information about CD126 on UniProt.org\u003cbr\u003e\nClone: W18166A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interluekin 6 receptor alpha, CD126\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866334318761,"sku":"160407","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-160407","provider":"Iright","version":"1.0","type":"link"}