{"product_id":"biolegend-160704","title":"Biolegend, 160704, PE anti-mouse IL-31 Antibody, 100μg","description":"\u003cp\u003eIL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130\/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK\/STAT, PI3K\/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-31\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2876573 (BioLegend Cat. No. 160703) AB_2876573 (BioLegend Cat. No. 160704)\u003cbr\u003e\nStructure: Member of IL-6 family of cytokines\u003cbr\u003e\nDistribution: Subset of CD4 T cells\u003cbr\u003e\nLigand\/Receptor: IL-31Ra\/OSMR\u003cbr\u003e\nCell Type: Lymphocytes, T cells, Th2, Thymocytes\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42. Arai I, et al. 2013. Exp. Dermatol. 22:669. Dai X, et al. 2013. PLoS One. 8:e67666. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5\u003cbr\u003e\nGene ID: 76399\u003cbr\u003e\nUniProt: View information about IL-31 on UniProt.org\u003cbr\u003e\nClone: W17037B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-31\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866310987945,"sku":"160704","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-160704","provider":"Iright","version":"1.0","type":"link"}