{"product_id":"biolegend-161606","title":"Biolegend, 161606, PE anti-mouse CD117 (c-kit) Antibody, 100μg","description":"\u003cp\u003eCD117 is a 145 kD immunoglobulin superfamily member also known as c-kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and\/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse c-kit transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: S18020H has been tested to block the ligand binding of SCF on c-kit which is determined by the phosphorylation of ERK1\/2 in c-kit signaling.\u003cbr\u003e\nProduct Citations: Tian C, et al. 2024. BMC Pharmacol Toxicol. 30:25. PubMed\u003cbr\u003e\nRRID: AB_2894652 (BioLegend Cat. No. 161605) AB_2894652 (BioLegend Cat. No. 161606)\u003cbr\u003e\nStructure: A 145 kD immunoglobulin superfamily member\u003cbr\u003e\nDistribution: Hematopoietic stem cells, mast cells, and some acute myeloid leukemia cells\u003cbr\u003e\nFunction: The development of hepatopoietic stem cells\u003cbr\u003e\nLigand\/Receptor: Steel factor, stem cell factor, and mast cell growth factor\u003cbr\u003e\nAntigen References: Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. Galli SJ, et al. 1994. Adv. Immunol. 55:1. Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759. Besmer P, et al. 1986. Nature. 320:415. Witte ON. 1990. Cell. 63:5.\u003cbr\u003e\nGene ID: 16590\u003cbr\u003e\nUniProt: View information about CD117 on UniProt.org\u003cbr\u003e\nClone: S18020H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SCO1, SOW3, CD117, Tr-kitm, Gsfsco5, c-kit\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866253381801,"sku":"161606","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-161606","provider":"Iright","version":"1.0","type":"link"}