{"product_id":"biolegend-164302","title":"Biolegend, 164302, Purified anti-mouse CD338 (ABCG2) Antibody, 100μg","description":"\u003cp\u003eCD338, also known as ABCG2 or BCRP1, is a 72 kD multi-drug resistance (MDR) protein member of ATP binding cassette (ABC) transporters. CD338 is expressed on stem cells from a variety of tissues and in many cancer types where it contributes to their resistance to chemotherapeutic drugs. ABCG2 is also up-regulated during erythroid differentiation. The expression of ABCG2 appears to be highly conserved as it has been identified in various species.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: mAbcg2-transfectants\/ epitope is listed as extracellular domain\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality Tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2924495 (BioLegend Cat. No. 164302)\u003cbr\u003e\nStructure: Member of the G subfamily of human ATP-binding cassette (ABC) transporter superfamily\u003cbr\u003e\nDistribution: Stem cells from multiple lineages, erythroid cells, cancerous cells\u003cbr\u003e\nFunction: Acts as a xenobiotic efflux transport protein that can transport chemotherapeutic drugs (making them resistant to the chemotherapy)\u003cbr\u003e\nAntigen References: Hoque KM, et al. 2020. Nat Commun. 11:2767. Jonker JW, et al. 2005. Nat Med. 11:127-9. Zhou E, et al. 2005. Blood. 105:2571-6. Kina T, et al. 2000. Br J Haem. 109:280-7.\u003cbr\u003e\nGene ID: 26357\u003cbr\u003e\nUniProt: View information about CD338 on UniProt.org\u003cbr\u003e\nClone: S17006D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ABCG2, CDw338, Bcrp1, MXR, ABCP, MRX, BMDP\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866228084905,"sku":"164302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-164302","provider":"Iright","version":"1.0","type":"link"}