{"product_id":"biolegend-165402","title":"Biolegend, 165402, Purified anti-mouse CD366 (Tim-3) Recombinant Antibody, 100μg","description":"\u003cp\u003eCD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b + macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone QA20A20 completely blocks the binding of reference clone RMT3-23 on target cells.\u003cbr\u003e\nRRID: AB_2924497 (BioLegend Cat. No. 165402)\u003cbr\u003e\nStructure: Transmembrane protein containing immunoglobulin domain and mucin-like domain with a predicted molecular weight of 31 kD; can exist as a soluble form lacking mucin and transmembrane domains.\u003cbr\u003e\nDistribution: Expressed on activated Th1 lymphocytes and CD11b+ macrophages\u003cbr\u003e\nFunction: May play a role in the development of immune responses and the development of Th1-mediated responses\u003cbr\u003e\nInteraction: Macrophages, Th1\u003cbr\u003e\nLigand\/Receptor: Putative ligand on resting CD4+ lymphocytes\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Th1\u003cbr\u003e\nBiology Area: Immunology, Inhibitory Molecules\u003cbr\u003e\nMolecular Family: CD Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Sabatos CA, et al. 2003. Nat Immunol. 4:1102-10. Kuchroo VK, et al. 2003. Nat Rev Immunol. 3:454-62. Mooney L, et al. 2002. Nature. 415:536-41.\u003cbr\u003e\nGene ID: 171285\u003cbr\u003e\nUniProt: View information about CD366 on UniProt.org\u003cbr\u003e\nClone: QA20A20\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD366, Tim-3, Hepatitis A virus cellular receptor 2 homolog (HAVcr-2)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866190696617,"sku":"165402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-165402","provider":"Iright","version":"1.0","type":"link"}