{"product_id":"biolegend-168102","title":"Biolegend, 168102, Purified anti-mouse Ly-6C Antibody, 100μg","description":"\u003cp\u003eMost hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte\/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8 + T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Ly6C-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-F - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. For immunohistochemical staining on frozen tissue sections, a concentration of 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Reference clone HK1.4 does not block the staining of clone S22006A.\u003cbr\u003e\nRRID: AB_3698942 (BioLegend Cat. No. 168102)\u003cbr\u003e\nStructure: 14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cysteine rich protein domain that incorporates O-linked carbohydrates.\u003cbr\u003e\nDistribution: Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes\/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.\u003cbr\u003e\nFunction: After cross linking Ly6C regulate endothelial adhesion of CD8 T cells through activation of LFA-1 at the expense of Ly6C down-regulation on the cell surface\u003cbr\u003e\nInteraction: Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells\u003cbr\u003e\nCell Type: Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Jutila MA, et al. 1988. Eur J Immunol. 18:1819-26. Cerwenka A, et al. 1998. J Immunol. 161:97-105.\u003cbr\u003e\nGene ID: 17067\u003cbr\u003e\nUniProt: View information about Ly-6C on UniProt.org\u003cbr\u003e\nClone: S22006A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lymphocyte antigen 6 complex, locus C\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866275401897,"sku":"168102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-168102","provider":"Iright","version":"1.0","type":"link"}