{"product_id":"biolegend-300002","title":"Biolegend, 300002, Purified anti-human LAP (TGF-β1) Antibody, 100μg","description":"\u003cp\u003eTGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-β to prevent its activity. TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8, and α8β1 through RGD domain. TGF-β plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TGF-β1 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S2006A can completely block the binding of clones TW4-2F8 and TW4-6H10 on target cells.\u003cbr\u003e\nRRID: AB_2892340 (BioLegend Cat. No. 300002)\u003cbr\u003e\nStructure: About 400 amino acids, N-terminal signal peptide is required for secretion from a cell, a pro-region (LAP) and C-terminal region that becomes the mature TGF-β molecule following its release from the pro-region by proteolytic cleavage.\u003cbr\u003e\nDistribution: Ubiquitously expressed by many kinds of cells\u003cbr\u003e\nFunction: Multifunctional cytokine, regulates cells proliferation, and differentiation\u003cbr\u003e\nLigand\/Receptor: TGF-βRI, -RII, -RIII, CD105, LTBP, integrins\u003cbr\u003e\nCell Type: B cells, Dendritic cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Adaptive Immunity, Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Inhibitory Molecules, Neuroinflammation, Neuroscience, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines, Growth Factors\u003cbr\u003e\nAntigen References: Yi JJ, et al. 2010. Cell. 142:144. Tran DQ, et al. 2009. Blood. 113:5125. Lu M, et al. 2002. J Cell Sci. 115:4641. Khalil N. 1999. Microbes Infect. 1:1255.\u003cbr\u003e\nGene ID: 7040\u003cbr\u003e\nUniProt: View information about LAP on UniProt.org\u003cbr\u003e\nClone: S20006A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Latency Associated Peptide (LAP), Transforming growth factor beta 1 (TGF-b1), TGFB1, DPD1, TGF-beta1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866263474345,"sku":"300002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-300002","provider":"Iright","version":"1.0","type":"link"}