{"product_id":"biolegend-300602","title":"Biolegend, 300602, Purified anti-human CD5 Antibody, 100μg","description":"\u003cp\u003eCD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1. It is a member of the scavenger receptor superfamily found on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions upon binding to ligands such as CD72.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Chimpanzee, Capuchin Monkey, Common Marmoset, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-F, WB - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, it is recommended to use at ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting2 and immunohistochemical staining of acetone-fixed frozen sections2,5.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Knapp W, et al. 1989. Leucocyte Typing IV Oxford University Press. New York. Renaudineau Y, et al. 2005. Blood 106:2781. (WB IHC) Porter JC and Hogg N. 1997. J. Cell Biol. 138:1437. Saliba AE, et al. 2010. P. Natl. Acad. Sci. USA 107:14524. PubMed Kap Y, et al. 2009. J. Histochem. Cytochem. 57:1159. (IHC)\u003cbr\u003e\nProduct Citations: Glass MC, et al. 2022. Cell Rep. 39:110728. PubMed Xu C, et al. 2022. iScience. 25:105123. PubMed Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed Olin A, et al. 2018. Cell. 174:1277. PubMed Del Alcazar D, et al. 2019. Cell Rep. 28:3047. PubMed Henrick BM, et al. 2021. Cell. . PubMed Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed Lakshmikanth T, et al. 2020. Cell Reports. 32(3):107923. PubMed Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed Sander J et al. 2017. Immunity. 47(6):1051-1066 . PubMed Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed\u003cbr\u003e\nRRID: AB_314088 (BioLegend Cat. No. 300602)\u003cbr\u003e\nStructure: Scavenger receptor superfamily, 67 kD\u003cbr\u003e\nDistribution: T cells, thymocytes, B cell subset, B cell CLL, peripheral blood dendritic cells\u003cbr\u003e\nFunction: Modulates TCR, BCR signaling, thymocyte maturation, T-B cell interaction\u003cbr\u003e\nLigand\/Receptor: CD72\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Leukemia, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Kipps T. 1988. Adv. Immunol. 47:117. 2. Resnick D, et al. 1993. Trends Biochem. Sci. 19:5. 3. Wood GS, et al. 1992. Am. J. Pathol. 14:789.\u003cbr\u003e\nGene ID: 921\u003cbr\u003e\nUniProt: View information about CD5 on UniProt.org\u003cbr\u003e\nClone: UCHT2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: III 518\u003cbr\u003e\nOther Names: Leu-1, Ly-1, T1, Tp67\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864077815977,"sku":"300602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-300602","provider":"Iright","version":"1.0","type":"link"}