{"product_id":"biolegend-302609","title":"Biolegend, 302609, APC anti-human CD25 Antibody, 25tests","description":"\u003cp\u003eCD25 is a 55 kD type I transmembrane glycoprotein also known as the low affinity IL-2 receptor α chain or Tac. It is expressed on progenitor lymphocytes, activated T and B cells, and activated monocytes\/macrophages. CD25 is also expressed on a subset of non-stimulated CD4 + T cells termed T regulatory cells. CD25 associates with the IL-2 receptor β (CD122) and common γ chains (CD132) to form the high affinity IL-2R complex.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Baboon, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include: immunocytochemistry3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. Kmieciak M, et al. 2009. J. Transl. Med. 7:89. (FC) PubMed Ernst CW, et al. 2007. Clin. Exp. Immunol. 148:271. (ICC) PubMed\u003cbr\u003e\nProduct Citations: Siepe DH, et al. 2022. Elife. 11:. PubMed Shang P, et al. 2022. Acta Biochim Biophys Sin (Shanghai). 54:1497. PubMed Wu X, et al. 2023. iScience. 26:106559. PubMed Beckinger S, et al. 2023. Front Oncol. 13:1160824. PubMed Koutsakos M, et al. 2022. Immunity. 55:1316. PubMed Martínez-Sabadell A, et al. 2022. Cell Rep. 41:111430. PubMed Sharma AL, et al. 2022. iScience. 25:105651. PubMed Ezeonwumelu IJ, et al. 2022. Int J Mol Sci. 23: . PubMed Wang P, et al. 2023. Front Immunol. 13:1104329. PubMed Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed Cao B, et al. 2022. Nat Commun. 13:6203. PubMed Fuhrman C, et al. 2015. J Immunol. 195: 145 - 155. PubMed Otano I, et al. 2021. Nat Commun. 12:7296. PubMed Goncharov MM, et al. 2022. Elife. 11:. PubMed Bednarski J, et al. 2016. J Exp Med. 213: 209 - 223. PubMed Nixon CC, et al. 2020. Cell Reports Medicine. 578(7793):160-165. PubMed Pedersen JG, et al. 2021. Front Microbiol. 12:763030. PubMed Wang J, et al. 2020. Cell. 183:1264. PubMed Soodgupta D, et al. 2019. Cell Rep. 29:829. PubMed Dean JW, et al. 2020. J Autoimmun. 108:102417. PubMed Alenazy MF, et al. 2021. Sci Rep. 11:5629. PubMed Juno JA, et al. 2020. Nat Med. 26:1428. PubMed Shevyrev D, et al. 2021. Exp Ther Med. 209:21. PubMed Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed Cai J, et al. 2021. eLife. 10:00. PubMed Luo Y, et al. 2021. Nat Commun. 12:3913. PubMed Su X, et al. 2022. J Transl Med. 20:378. PubMed Chulpanova DS, et al. 2021. Biology (Basel). 10:. PubMed Roshani Asl E, et al. 2021. J Cell Physiol. 236:7071. PubMed Martínez–Fábregas J, et al. 2019. Elife. 8:e49314. PubMed Shemesh A, et al. 2022. J Exp Med. 219:. PubMed Ye Z, et al. 2021. NPJ Aging Mech Dis. 7:4. PubMed Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed Burke MT, et al. 2017. Transplant Direct. 3:e171. PubMed Chen J, et al. 2017. Sci Rep. 10.1038\/s41598-017-11056-9. PubMed Wallstabe J, et al. 2020. ALTEX. 37:429. PubMed Winkler C, et al. 2021. JCI Insight. 6:. PubMed Zhu P, et al. 2022. Cell Commun Signal. 20:121. PubMed Hu JQ, et al. 2020. J Cancer. 3.409722222. PubMed Trabanelli S, et al. 2014. J Immunol. 192:1231. PubMed Yamaguchi K, et al. 2018. Cancer Sci. 109:3032. PubMed Li Y, et al. 2022. Bioengineered. 13:4730. PubMed\u003cbr\u003e\nRRID: AB_314279 (BioLegend Cat. No. 302609) AB_314280 (BioLegend Cat. No. 302610)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, 55 kD\u003cbr\u003e\nDistribution: Activated T cells and B cells, monocytes\/macrophages, Treg\u003cbr\u003e\nFunction: Associates with IL-2 receptor β (CD122) and γ chains (CD132) to form high affinity IL-2R complex\u003cbr\u003e\nLigand\/Receptor: IL-2\u003cbr\u003e\nCell Type: B cells, Macrophages, Monocytes, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Taniguchi T, et al. 1993. Cell 73:5. 2. Waldmann T. 1991. J. Biol. Chem. 266:2681.\u003cbr\u003e\nGene ID: 3559\u003cbr\u003e\nUniProt: View information about CD25 on UniProt.org\u003cbr\u003e\nClone: BC96\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V T-072\u003cbr\u003e\nOther Names: Low affinity IL-2R, IL-2R α chain, Tac, p55\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862902788265,"sku":"302609","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-302609","provider":"Iright","version":"1.0","type":"link"}