{"product_id":"biolegend-304516","title":"Biolegend, 304516, APC\/Cyanine7 anti-human CD184 (CXCR4) Recombinant Antibody, 100tests","description":"\u003cp\u003eCD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes\/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CXCR4 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool).\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: This recombinant antibody clone is derived from clone S17017A.\u003cbr\u003e\nStructure: Rhodopsin family, G-protein linked seven transmembrane glycoprotein, 45 kD\u003cbr\u003e\nDistribution: T cells and B cells, dendritic cells, monocytes, granulocytes, hematopoietic progenitors, endothelial cells\u003cbr\u003e\nFunction: B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, cerebellar development\u003cbr\u003e\nLigand\/Receptor: SDF-1 receptor, coreceptor for X4 HIV-1\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Granulocytes, Hematopoietic stem and progenitors, Mesenchymal cells, Monocytes, Neural Stem Cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: Berger EA, et al. 1999. Annu Rev Immunol. 17:657-700. Loetscher P, et al. 2000. Adv Immunol. 74:127-80. Murphy PM, et al. 2000. Pharmacol Rev. 52:145-76.\u003cbr\u003e\nGene ID: 7852\u003cbr\u003e\nUniProt: View information about CD184 on UniProt.org\u003cbr\u003e\nClone: QA18A64\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CXCR4, Fusin\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866183618729,"sku":"304516","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-304516","provider":"Iright","version":"1.0","type":"link"}