{"product_id":"biolegend-316810","title":"Biolegend, 316810, Purified anti-human CD158b\/j (KIR2DL2\/L3\/S2) Antibody, 100μg","description":"\u003cp\u003eCD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.  CD158b1, CD158b2, and CD158j are 33-38 kD two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs for KIR2DL2\/KIR2DL3 or a short cytoplasmic tail with an ITAM motif for KIR2DS2. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL2\/KIR2DS2\/KIR2DL3 has been reported to bind to certain HLA-C antigens on a target cell (HLA-C*01, HLA-C*03, HLA-C*07, for example).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human KIR2DS2 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S22038E is able to block the binding of clone DX27 on target cells and is partially blocked by DX27. Based on in-house testing on different KIR-expressing transfectants, clone S22038E does not interact with other KIR protein family members.\u003cbr\u003e\nRRID: AB_3698973 (BioLegend Cat. No. 316810)\u003cbr\u003e\nStructure: 33-38 kD two Ig-like extracellular domain glycoprotein\u003cbr\u003e\nDistribution: Subset of NK cells, subset of T cells\u003cbr\u003e\nFunction: NK cell regulation\u003cbr\u003e\nLigand\/Receptor: Some HLA-C molecules\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Vilches C, et al. 2002. Annu Rev Immunol. 92:107361. Middleton D, et al. 2010. Immunol. 123:8. Moesta AK, et al. 2012. Frontiers Immu. 3:336. David G, et al. 2013. Journal of Immu. 191:9.\u003cbr\u003e\nGene ID: 38033804100132285\u003cbr\u003e\nUniProt: View information about CD158b CD158j on UniProt.org\u003cbr\u003e\nClone: S22038E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD158b1 (KIR2DL2, p58.2, NKAT6), CD158b2 (KIR2DL3, p58.3, NKAT2), CD158j (KIR2DS2, p50.2), KIR-NKAT2\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866278383785,"sku":"316810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-316810","provider":"Iright","version":"1.0","type":"link"}