{"product_id":"biolegend-317709","title":"Biolegend, 317709, Purified anti-human CD158f (KIR2DL5) Antibody, 100μg","description":"\u003cp\u003eCD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.  CD158f, also known as KIR2DL5, is a 40 kD two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with an ITIM motif as well as an immunoreceptor tyrosine-based switch motif (ITSM). It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL5 has been reported to bind to CD155 resulting in immune inhibitory suppression of NK cells. 4\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human KIR2DL5 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S22010E does not the block binding of clone UP-R1 on target cells and is not blocked by UP-R1. Clone S22010E can bind to multiple SNP variants of KIR2DL5. Based on in-house testing on different KIR-expressing transfectants, clone S22010E does not interact with other KIR protein family members.\u003cbr\u003e\nRRID: AB_3698977 (BioLegend Cat. No. 317709)\u003cbr\u003e\nStructure: 40 kD two Ig-like extracellular domain glycoprotein\u003cbr\u003e\nDistribution: Subset of NK cells, subset of T cells\u003cbr\u003e\nFunction: NK Cell regulation\u003cbr\u003e\nLigand\/Receptor: CD155\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Vilches, C. et al. 2002. Annu. Rev. Immunol. 2002:20:217-51 Middleton, D. et al. 2010. Immunol. 123:8 Ernesto, E. et al. 2007. Journal of Immunol. 178(7):4402-10 Ren, X. et al. 2022. J. Clin Invest. 132.22\u003cbr\u003e\nGene ID: 57292\u003cbr\u003e\nUniProt: View information about CD158f on UniProt.org\u003cbr\u003e\nClone: S22010E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD158f, Killer Cell Immunoglobulin-Like Receptor 2DL5, CD158F1, 2DL5.1, KIR2DL5A, KIR2DL5B, CD158F2, KIR2DLX\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866275532969,"sku":"317709","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-317709","provider":"Iright","version":"1.0","type":"link"}