{"product_id":"biolegend-321809","title":"Biolegend, 321809, Purified anti-human OSMR Antibody, 100μg","description":"\u003cp\u003eOncostatin M receptor (OSMR), also known as IL-31 receptor subunit beta, is a member of the IL-6 receptor family. It is expressed in bone marrow, endothelium, liver, lung and skin tissues. OSMR forms the type II OSM receptor complex when paired with interleukin 6 signal transducer (gp130) and forms the IL-31 receptor when complexed with interleukin 31 receptor A (IL31RA). The binding of OSM to either of these receptors triggers activation of the JAK-STAT signaling pathway.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human OSMR protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S22005D does not affect the binding of clone S22005H on target cells.\u003cbr\u003e\nRRID: AB_3720538 (BioLegend Cat. No. 321809)\u003cbr\u003e\nStructure: Transmembrane immunoglobulin-like glycoprotein, 130 kD\u003cbr\u003e\nDistribution: Hepatocytes, mesothelial cells, glial cells and epithelial cells\u003cbr\u003e\nFunction: Ligand binding, signal transduction\u003cbr\u003e\nInteraction: gp130, IL-31RA\u003cbr\u003e\nLigand\/Receptor: IL-31, OSM\u003cbr\u003e\nCell Type: Epithelial cells, Macrophages, Mesenchymal cells, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Mosley B, et al. 1996. J Biol Chem. 271:32635. Auguste P, et al. 1997. J Biol Chem. 272:15760. Hermanns HM, et al. 1999. J. Immunol. 163:6651.\u003cbr\u003e\nGene ID: 9180\u003cbr\u003e\nUniProt: View information about OSMR on UniProt.org\u003cbr\u003e\nClone: S22005D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: OSMRβ, IL-31R\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866275238057,"sku":"321809","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-321809","provider":"Iright","version":"1.0","type":"link"}