{"product_id":"biolegend-323202","title":"Biolegend, 323202, Purified anti-human CD105 Antibody, 100μg","description":"\u003cp\u003eCD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: L-cells transfected with human CD105\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Bühring HJ, et al. 1991. Leukemia 5:841. Vogel W, et al. 2002. Haematologica 88:126. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed HonMou O, et al. 2011. Brain. 134:1790. PubMed Herrera MB, et al. 2013. Hepatology. 57:311. PubMed Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed\u003cbr\u003e\nProduct Citations: Saggu G, et al. 2018. Nat Commun. 9:5058. PubMed Vivanco Gonzalez N, et al. 2022. STAR Protoc. 3:101280. PubMed Bashth OS, et al. 2020. Biomater Sci. 4.128472222. PubMed Okubo K, et al. 2021. Cell Reports. 35(7):109142. PubMed Baskar R, et al. 2022. Cell Rep Methods. 2:. PubMed Boulanger MD, et al. 2022. PLoS One. 17:e0269316. PubMed Ran LJ, et al. 2018. Mol Med Rep. 18:723. PubMed\u003cbr\u003e\nRRID: AB_755954 (BioLegend Cat. No. 323202)\u003cbr\u003e\nStructure: Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD\u003cbr\u003e\nDistribution: Endothelial cells, activated monocytes\/macrophages, bone marrow stromal cells, hematopoietic stem\/progenitor cells\u003cbr\u003e\nFunction: Modulates cellular response to TGF-ß, involved in vascular development and remodelling\u003cbr\u003e\nLigand\/Receptor: TGF-ß1, TGF-ß3\u003cbr\u003e\nCell Type: Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Mesenchymal Stem Cells, Monocytes\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York. 2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195.\u003cbr\u003e\nGene ID: 2022\u003cbr\u003e\nUniProt: View information about CD105 on UniProt.org\u003cbr\u003e\nClone: 43A3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Endoglin\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862404747433,"sku":"323202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-323202","provider":"Iright","version":"1.0","type":"link"}