{"product_id":"biolegend-329802","title":"Biolegend, 329802, Purified anti-human CD275 (B7-H2, B7-RP1, ICOSL) Antibody, 100μg","description":"\u003cp\u003eB7-H2, a member of the B7 family and the immunoglobulin superfamily, is a 40 kD protein also known as B7RP-1, B7h, B7-H2, GL50 and ICOS Ligand. Human B7-H2 is expressed by B lymphocytes, activated monocytes\/macrophages, and dendritic cells. B7-H2 binds to a CD28-like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. The interaction of ICOS with B7-H2 plays an important role in the T cell costimulation pathway.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human B7H2-mIg fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Qian X, et al. 2006. Eur J Immunol. 36:906-918. Ribot JC, et al. 2012. J. Immunol. 189:1202. PubMed.\u003cbr\u003e\nProduct Citations: Ribot J, et al. 2012. J Immunol. 189:1202. PubMed Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed\u003cbr\u003e\nRRID: AB_960990 (BioLegend Cat. No. 329801)\u003cbr\u003e\nStructure: Ig superfamily, B7 family, 40 kD\u003cbr\u003e\nDistribution: B cells and dendritic cells\u003cbr\u003e\nFunction: Binds ICOS on antigen-activated T cells and mediates proliferation and cytokine production\u003cbr\u003e\nLigand\/Receptor: ICOS\u003cbr\u003e\nCell Type: B cells, Dendritic cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Qian X, et al. 2006. Eur J Immunol. 36:906-918.\u003cbr\u003e\nGene ID: 23308\u003cbr\u003e\nUniProt: View information about CD275 on UniProt.org\u003cbr\u003e\nClone: 9F.8A4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B7-H2, B7H2, B7-RP1, ICOSL, ICOS-L\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862512029865,"sku":"329802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-329802","provider":"Iright","version":"1.0","type":"link"}