{"product_id":"biolegend-333808","title":"Biolegend, 333808, PE anti-human CD68 Antibody, 100tests","description":"\u003cp\u003eCD68 is a 110 kD glycoprotein, also known as macrosialin, belonging to the sialomucin family. It is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (LAMPs). CD68 is predominately expressed in cytoplasmic granules of monocytes\/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported application: immunohistochemical staining of frozen tissue sections. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Doussis IA, et al. 1993. J. Clin. Pathol. 46:334. Davey FR, et al. 1988. J. Clin. Pathol. 41:753. Bushway ME, et al. 2014. Biol Reprod. 90(5): 110. (IF) PubMed\u003cbr\u003e\nProduct Citations: Liao Y, et al. 2023. Am J Transl Res. 15:817. PubMed Duraiswamy J, et al. 2021. Cancer Cell. 39:1623. PubMed Hu Z, et al. 2022. Nat Metab. 4:759. PubMed Lin H, et al. 2021. Blood Adv. 5:3457. PubMed Obradovic A, et al. 2021. Cell. 184(11):2988-3005.e16. PubMed Shinohara H, et al. 2017. J Immunol. 10.4049\/jimmunol.1700167. PubMed Wu H, et al. 2022. Biomolecules. 12:. PubMed Ronaldson-Bouchard K, et al. 2022. Nat Biomed Eng. 6:351. PubMed Aung A, et al. 2020. Cancer Res. 80:263. PubMed Shen XR, et al. 2021. Viruses. 13:. PubMed Que Y, et al. 2021. Front Immunol. 12:653030. PubMed Murphy DM, et al. 2022. J Clin Invest. Online ahead of print. PubMed\u003cbr\u003e\nRRID: AB_1089057 (BioLegend Cat. No. 333807) AB_1089056 (BioLegend Cat. No. 333808)\u003cbr\u003e\nStructure: Sialomucin family, 110 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells, granulocytes, subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, endothelial cells\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Hematopoietic stem and progenitors, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Holness CL and Simmons DL. 1993. Blood 81:1607. 2. Gottfried E, et al. 2008. Scand. J. Immunol. 67:453. 3. Hameed A, et al. 1994. Hum. Pathol. 25:872.\u003cbr\u003e\nGene ID: 968\u003cbr\u003e\nUniProt: View information about CD68 on UniProt.org\u003cbr\u003e\nClone: Y1\/82A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI MR23\u003cbr\u003e\nOther Names: Macrosialin\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864103047337,"sku":"333808","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-333808","provider":"Iright","version":"1.0","type":"link"}