{"product_id":"biolegend-333828","title":"Biolegend, 333828, Brilliant Violet 421™ anti-human CD68 Antibody, 100tests","description":"\u003cp\u003eCD68 is a 110 kD glycoprotein, also known as macrosialin, belonging to the sialomucin family. It is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (LAMPs). CD68 is predominately expressed in cytoplasmic granules of monocytes\/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450\/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication Notes: Additional reported application: immunohistochemical staining of frozen tissue sections. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Doussis IA, et al. 1993. J. Clin. Pathol. 46:334. Davey FR, et al. 1988. J. Clin. Pathol. 41:753. Bushway ME, et al. 2014. Biol Reprod. 90(5): 110. (IF) PubMed\u003cbr\u003e\nProduct Citations: Mavropoulos A, et al. 2023. Mod Pathol. 100195:36. PubMed Sefik E, et al. 2022. Nature. 606:585. PubMed Sefik E, et al. 2021. Nat Biotechnol. . PubMed Wu Y, et al. 2022. J Cancer Res Clin Oncol. . PubMed\u003cbr\u003e\nRRID: AB_2800881 (BioLegend Cat. No. 333827) AB_2800882 (BioLegend Cat. No. 333828)\u003cbr\u003e\nStructure: Sialomucin family, 110 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells, granulocytes, subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, endothelial cells\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Hematopoietic stem and progenitors, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Holness CL and Simmons DL. 1993. Blood 81:1607. 2. Gottfried E, et al. 2008. Scand. J. Immunol. 67:453. 3. Hameed A, et al. 1994. Hum. Pathol. 25:872.\u003cbr\u003e\nGene ID: 968\u003cbr\u003e\nUniProt: View information about CD68 on UniProt.org\u003cbr\u003e\nClone: Y1\/82A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI MR23\u003cbr\u003e\nOther Names: Macrosialin\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What is the F\/P ratio range of our BV421™ format antibody reagents?\u003cbr\u003e\nA: It is lot-specific. On average it ranges between 2-4.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864103375017,"sku":"333828","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-333828","provider":"Iright","version":"1.0","type":"link"}