{"product_id":"biolegend-335612","title":"Biolegend, 335612, Purified anti-human EGFRvIII Recombinant Antibody, 100μg","description":"\u003cp\u003eEpidermal growth factor receptor variant III (EGFRvIII) arises from an in-frame deletion of exons 2 to 7 in the extracellular region of EGFR, resulting in a truncated receptor that is constitutively active. This mutation is cancer-specific and is present in approximately 50% of glioblastoma tumors.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Peptide LEEKKGNYVVTDHC conjugated to KLH\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_3675056 (BioLegend Cat. No. 335612)\u003cbr\u003e\nStructure: Deletion of exons 2-7 of the EGFR gene. Molecular mass of approximately 145 kD.\u003cbr\u003e\nDistribution: Present in approximately 50% of glioblastoma tumors\u003cbr\u003e\nFunction: Pro-tumorigenic (promotes tumor growth, survival, invasion, stemness, metabolism, and angiogenesis).\u003cbr\u003e\nBiology Area: Cancer Biomarkers\u003cbr\u003e\nAntigen References: Hui G, et al. 2013. FEBS Journal. 280:21.\u003cbr\u003e\nGene ID: 1956\u003cbr\u003e\nUniProt: View information about EGFRvIII on UniProt.org\u003cbr\u003e\nClone: DH8.3.Rec\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: EGFRv3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863009546409,"sku":"335612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-335612","provider":"Iright","version":"1.0","type":"link"}