{"product_id":"biolegend-335853","title":"Biolegend, 335853, PE anti-human IDO1 Antibody, 25tests","description":"\u003cp\u003eIDO1 is also known as Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, and Indoleamine-pyrrole 2,3-dioxygenase. IDO1 is a ubiquitously expressed cytoplasmic protein with a predicted molecular weight of approximately 45 kD. It is one of the best known IFN-γ inducible genes. The product of IDO gene catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated to protect against intracellular and extracellular pathogens. It also has been shown to maintain the special immune suppressive status of immune-privileged sites such as the brain, eyes, kidney, and placenta.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant protein, full length human IDO\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_3662230 (BioLegend Cat. No. 335853) AB_3662230 (BioLegend Cat. No. 335854)\u003cbr\u003e\nStructure: Heme-containing enzyme of 403 amino acids with a predicted molecular weight of 45 kD.\u003cbr\u003e\nDistribution: Cytoplasm\u003cbr\u003e\nFunction: Dioxygenase, Oxidoreductase\u003cbr\u003e\nLigand\/Receptor: Heme, Iron, Metal binding\u003cbr\u003e\nCell Type: Dendritic cells, Eosinophils, Langerhans cells, Macrophages, Schwann Cells, T cells\u003cbr\u003e\nBiology Area: Immuno-Oncology, Immunology, Inhibitory Molecules\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: Yamazaki F, et al.1985. The Biochemical Journal. 230: 635–8. Prendergast GC, et al. 2014. Frontiers in Immunology. 5:585. Habara-Ohkubo A, et al. 1991. Gene. 105:221. Munn DH, et al. 2002. Science. 297:1867. Frumento G, et al. 2002. J Exp Med. 196:459. Muller AJ, et al. 2005. Nature Med. 11:312. Löb S, et al. 2009. Nature Rev Cancer. 9:445-52.\u003cbr\u003e\nGene ID: 15930\u003cbr\u003e\nUniProt: View information about IDO1 on UniProt.org\u003cbr\u003e\nClone: W20099D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase\u003cbr\u003e\nIsotype: Rat IgG2b, λ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866421121193,"sku":"335853","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-335853","provider":"Iright","version":"1.0","type":"link"}