{"product_id":"biolegend-337218","title":"Biolegend, 337218, APC\/Cyanine7 anti-human CD11c Antibody, 100tests","description":"\u003cp\u003eCD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin α x and CR4. CD11c non-covalently associates with integrin β 2 (CD18) and is expressed on monocytes\/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42. Rezzonico R, et al. 2001. Blood 97:2932. Sadhu C, et al. 2007. J. Leukoc. Biol. 81:1395. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)\u003cbr\u003e\nProduct Citations: Wu X, et al. 2023. iScience. 26:106559. PubMed De Hert E, et al. 2022. Int J Mol Sci. 23:. PubMed Cavalli G, et al. 2016. Proc Natl Acad Sci U S A. 113: 1363 - 1368. PubMed Canavan M, et al. 2018. JCI Insight. 3:. PubMed Liu C, et al. 2021. Cell Res. 31:1106. PubMed Izquierdo-Useros N, et al. 2012. PLoS One. 10:e1001315. PubMed Forbester JL, et al. 2020. J Virol. 94:. PubMed Wouters K, et al. 2017. Sci Rep. 7:42665. PubMed Grandclaudon M, et al. 2019. Cell. 179:432. PubMed Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed Fredriksson K, et al. 2014. J Immunol. 192:4497. PubMed Richardson JR, et al. 2018. Front Immunol. 2.182638889. PubMed Verboven K, et al. 2018. Sci Rep. 8:4677. PubMed Zhang X, et al. 2021. Nat Commun. 12:4536. PubMed Céspedes PF, et al. 2022. Nat Commun. 13:3460. PubMed Jardine L, et al. 2019. Nat Commun. 10:1999. PubMed Koh WH, et al. 2020. STAR Protoc. 1:100203. PubMed Ceglia V, et al. 2021. J Immunol. 207:2060. PubMed Milne P, et al. 2015. Blood. 125:470. PubMed Zimmermann M, et al. 2019. Front Immunol. 10:829. PubMed Cytlak U, et al. 2020. Immunity. 53(2):353-370. PubMed Ceglia V, et al. 2022. Front Immunol. 12:786144. PubMed\u003cbr\u003e\nRRID: AB_10661724 (BioLegend Cat. No. 337217) AB_10662746 (BioLegend Cat. No. 337218)\u003cbr\u003e\nStructure: Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 145-150 kD\u003cbr\u003e\nDistribution: Myeloid, dendritic cells, NK cells, B cells and T cell subsets\u003cbr\u003e\nFunction: Adhesion, CTL killing Ligand Receptor: CD54, fibrinogen, iC3b, ICAM-1, ICAM-4 Antigen\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Neutrophils, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Petty H. 1996. Immunol. Today 17:209. 2. Springer T. 1994. Cell 76:301. 3. Ihanus E, et al. 2007. Blood 109:802-810.\u003cbr\u003e\nGene ID: 3687\u003cbr\u003e\nUniProt: View information about CD11c on UniProt.org\u003cbr\u003e\nClone: Bu15\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V S143\u003cbr\u003e\nOther Names: Integrin αx subunit, ITGAX, CR4, p150\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862919106729,"sku":"337218","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-337218","provider":"Iright","version":"1.0","type":"link"}