{"product_id":"biolegend-339008","title":"Biolegend, 339008, APC anti-human CD122 (IL-2Rβ) Antibody, 100tests","description":"\u003cp\u003eCD122 is a 70-75 kD type I transmembrane glycoprotein and member of the Ig superfamily. It is IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. CD122 is constitutively expressed by NK cells and at lower levels by a subset of T cells. Its expression is upregulated upon activation. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: TL-Mor cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include (for the relevant formats) include: immunoprecipitation, blocking of IL-2 binding to CD122, and partial inhibition of IL-2 induced cell proliferation.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Takeshita T, et al. 1989. J. Exp. Med. 169:1323.\u003cbr\u003e\nProduct Citations: Yen M, et al. 2022. Cell. 185:1414. PubMed Marra P, et al. 2014. Cancer Res. 74:4908. PubMed Zeng W, et al. 2017. Front Immunol. 0.806944444. PubMed Shiozawa S, et al. 2022. iScience. 25:103537. PubMed Shemesh A, et al. 2022. J Exp Med. 219:. PubMed Fernandez IZ, et al. 2019. J Exp Med. 216:1255. PubMed\u003cbr\u003e\nRRID: AB_2248891 (BioLegend Cat. No. 339007) AB_2123575 (BioLegend Cat. No. 339008)\u003cbr\u003e\nStructure: Ig superfamily, forms high affinity IL-2 receptor with CD25 and CD132 chains or intermediate affinity receptor with CD132 alone, 70-75 kD\u003cbr\u003e\nDistribution: NK cells, T subset\u003cbr\u003e\nFunction: Critical component of IL-2 and IL-15 signaling\u003cbr\u003e\nLigand\/Receptor: IL-2, IL-15\u003cbr\u003e\nCell Type: NK cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley \u0026amp; Sons Inc, Publication 2. Minami Y, et al. 1993. Annu. Rev. Immunol. 11:245. 3. Suzuki H, et al. 1995. Science 268:1472.\u003cbr\u003e\nGene ID: 3560\u003cbr\u003e\nUniProt: View information about CD122 on UniProt.org\u003cbr\u003e\nClone: TU27\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V C050\u003cbr\u003e\nOther Names: IL-2 Receptor β chain, IL-2Rβ\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864043540649,"sku":"339008","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-339008","provider":"Iright","version":"1.0","type":"link"}