{"product_id":"biolegend-340305","title":"Biolegend, 340305, APC anti-human CD307e (FcRL5) Antibody, 25tests","description":"\u003cp\u003eFcRL5, also known as CD307e, CD307, IRTA2, FcRH5, and BXMAS1, is a 106 kD type I transmembrane glycoprotein composed of six-eight extracellular Ig like C2 domains and two cytoplasmic ITIM motifs. The FcRL5 gene is located on chromosome 1q21 and is normally expressed by tonsillar plasma cells and germinal center B cells. It has been suggested that FcRL5 contributes to B cell maturation and B cell receptor modulation. The identification of FcRL5 on a number of transformed cell types including hairy cell leukemia, mantle cell lymphoma, chronic lymphocytic lymphoma, and Burkitt’s lymphoma has prompted interest in it as a potential biomarker or target for immunotherapy. FcRL5 binds all aggregated IgG isotypes.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: P815 cells transfected with FcRL5\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation and blocking1. mAb 509f6 is able to block the binding of FcRL5 to all aggregated IgG isotypes.1\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)\u003cbr\u003e\nProduct Citations: Hata K, et al. 2023. Front Immunol. 14:1145814. PubMed Jiang D, et al. 2023. Nat Commun. 14:3642. PubMed SoRelle ED, et al. 2022. Front Immunol. 13:1001145. PubMed Sutton HJ, et al. 2021. Cell Reports. 34(6):108684. PubMed Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed\u003cbr\u003e\nRRID: AB_2564326 (BioLegend Cat. No. 340305) AB_2564327 (BioLegend Cat. No. 340306)\u003cbr\u003e\nStructure: 106 kD, Fc receptor like, type 1 transmembrane protein, 6-8 Ig like C2 domains, 2 cytoplasmic ITIM motifs.\u003cbr\u003e\nDistribution: Germinal center B cells, tonsillar plasma cells.\u003cbr\u003e\nLigand\/Receptor: Aggregated IgG\u003cbr\u003e\nCell Type: B cells, Plasma cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Davis R, et al. 2007. Annu. Rev. Immunol. 207:528. 2. Mohan J, et al. 2006. Blood 107:4433. 3. Ise T, et al. 2007. Leukemia. 21:169.\u003cbr\u003e\nGene ID: 83416\u003cbr\u003e\nUniProt: View information about CD307e on UniProt.org\u003cbr\u003e\nClone: 509f6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD307, IRTA2, FcRH5, IFGP5, BXMAS1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862427750569,"sku":"340305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-340305","provider":"Iright","version":"1.0","type":"link"}