{"product_id":"biolegend-343205","title":"Biolegend, 343205, APC anti-human CD43 Antibody, 25tests","description":"\u003cp\u003eCD43, also known as Ly-48, leukosialin, sialophorin, leukocyte sialoglycoprotein, and W3\/13, is a large single chain, type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesion and anti-adhesion as well as costimulation of T cell activation and survival, and induction of apoptosis of T cells and hematopoietic progenitors.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: MV4-11 cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Rosenkranz AR, et al. 1993. Immunology. 80:431 Skubitz KM, et al. 1998. J. Leukoc. Biol. 64:800\u003cbr\u003e\nProduct Citations: Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed Filipello F, et al. 2023. Acta Neuropathol. 145:749. PubMed Grubman A, et al. 2020. Stem Cell Reports. 1.290277778. PubMed Guney-Esken G, et al. 2021. Stem Cell Res Ther. 12:287. PubMed Ng E, et al. 2016. Nat Biotechnol. 34:1168-1179. PubMed Rai MA, et al. 2020. Retrovirology. 17:35. PubMed Bruveris FF, et al. 2020. Development. 147:00:00. PubMed Guney-Esken G, et al. 2021. Methods Mol Biol. 2549:23. PubMed\u003cbr\u003e\nRRID: AB_2194073 (BioLegend Cat. No. 343205) AB_2194072 (BioLegend Cat. No. 343206)\u003cbr\u003e\nStructure: Single chain, type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites, 95-130 kD.\u003cbr\u003e\nDistribution: Most hematopoietic cells, including peripheral T cells, NK cells, granulocytes, monocytes, thymocytes, platelets, plasma cells, activated B cells, and hemotopoietic progenitor cells.\u003cbr\u003e\nFunction: Plays dual roles in cell-cell adhesion and anti-adhesion, costimulation of cell activation and survival, inducing apoptosis of T cells and hematopoietic progenitors.\u003cbr\u003e\nLigand\/Receptor: CD54, Siglec-1\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Neil Barclay A, et al. 1997. The Leucocyte Antigen Facts Book:Second Edition. Page 238 2. Killeen A, et al. 1987. EMBO J. 6:4029. 3. Thurman EC, et al. 1998. Intl. Immunol. 10:691. 4. Onami TM, et al. 2002. J. Immunol. 168:6022. 5. Tong J, et al. 2004. J. Exp. Med. 199:1277. 6. Jones AT, et al. 1994. J. Immunol. 153:3426.\u003cbr\u003e\nGene ID: 6693\u003cbr\u003e\nUniProt: View information about CD43 on UniProt.org\u003cbr\u003e\nClone: CD43-10G7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Ly-48, Leukosialin, Sialophorin, Leukocyte Sialoglycoprotein\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862985167017,"sku":"343205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-343205","provider":"Iright","version":"1.0","type":"link"}