{"product_id":"biolegend-343607","title":"Biolegend, 343607, APC anti-human CD34 Antibody, 25tests","description":"\u003cp\u003eCD34, also known as gp105-120, is a type I monomeric sialomucin-like glyco-phosphoprotein with an approximate molecular weight of 105-120 kD. It is selectively expressed on the majority of hematopoietic stem\/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue. CD34 is a commonly used marker for identifying human hematopoietic stem\/progenitor cells. Based on different sensitivities, four groups of epitopes of CD34 have been described. CD34 mediates cell adhesion and lymphocytes homing through binding to L-selectin and E-selectin ligands.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: The 561 antibody recognizes a class III group epitope, which is resistant to sialidase\/glycolyprotease and chymopapain treatment.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Croockewit AJ, et al. 1998. Scand. J. Immunol. 47:82. Rosenzweig M, et al. 2001. J. Med. Primatol. 30:36.\u003cbr\u003e\nProduct Citations: Mendt M, et al. 2018. JCI Insight. 9:1523. PubMed Park J, et al. 2022. Bone Joint Res. 11:777. PubMed Shiroshita K, et al. 2022. Cell Rep Methods. 2:100354. PubMed Gao Y, et al. 2023. iScience. 26:106729. PubMed Park J, et al. 2021. Exp Ther Med. 22:808. PubMed Voit RA, et al. 2023. Nat Immunol. 24:69. PubMed Liu Y, et al. 2022. Signal Transduct Target Ther. 7:347. PubMed Lee JK, et al. 2020. Sci Rep. 2.567361111. PubMed Guzzi N et al. 2018. Cell. 173(5):1204-1216 . PubMed Shi L, et al. 2021. Stem Cell Res Ther. 12:147. PubMed Gumber D, et al. 2020. eLife. 9:00. PubMed Riether C, et al. 2021. Cell Reports. 34(4):108663. PubMed Jiang S, et al. 2021. Bioact Mater. 2711:6. PubMed Watanabe D, et al. 2018. Stem Cells Transl Med. 7:34. PubMed Hasaart KAL, et al. 2020. Sci Rep. 10:12991. PubMed Hinterbrandner M, et al. 2021. JCI Insight. 6:e151797. PubMed Morton JJ, et al. 2018. Mol Carcinog. 57:1651. PubMed Xiao X, et al. 2019. Cell Discov. 5:2. PubMed Bak RO, et al. 2018. Nat Protoc. 13:358. PubMed Liu Z, et al. 2017. Cancer Lett . 10.1016\/j.canlet.2017.04.017. PubMed Hasan S, et al. 2017. Am J Physiol Cell Physiol. 312:C286. PubMed Li J, et al. 2021. Mol Med Rep. 1:23. PubMed Morton JJ, et al. 2020. Molecular Cancer Research. 19(2):346-357. PubMed Lu J, et al. 2021. Front Immunol. 12:732612. PubMed Kim MY, et al. 2018. Cell. 173:1439. PubMed Gomez–Ospina N, et al. 2019. Nat Commun. 3.225694444. PubMed Lee JK, et al. 2021. Cells. 10:. PubMed Bhatwadekar A, et al. 2010. Diabetes. 59:2010. PubMed Morvan MG, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed Rodriguez A, et al. 2021. Cell Stem Cell. 28:33. PubMed Asada S, et al. 2018. Nat Commun. 9:2733. PubMed Serr I, et al. 2016. Nat Commun. 7:10991. PubMed Qiu X, et al. 2022. Cell. 185:690. PubMed\u003cbr\u003e\nRRID: AB_2074356 (BioLegend Cat. No. 343607) AB_2228972 (BioLegend Cat. No. 343608)\u003cbr\u003e\nStructure: 105-120 kD single chain mucin-like glycoprotein\u003cbr\u003e\nDistribution: Hematopoietic stem\/progenitor cells, bone marrow stromal cells, endothelial cells, embryonic fibroblasts\u003cbr\u003e\nFunction: Cell adhesion\u003cbr\u003e\nLigand\/Receptor: L-selecin, E-selectin\u003cbr\u003e\nCell Type: Endothelial cells, Fibroblasts, Hematopoietic stem and progenitors\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 947\u003cbr\u003e\nUniProt: View information about CD34 on UniProt.org\u003cbr\u003e\nClone: 561\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gp105-120, My10, Mucosialin\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862444429481,"sku":"343607","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-343607","provider":"Iright","version":"1.0","type":"link"}