{"product_id":"biolegend-343618","title":"Biolegend, 343618, Alexa Fluor® 647 anti-human CD34 Antibody, 100tests","description":"\u003cp\u003eCD34, also known as gp105-120, is a type I monomeric sialomucin-like glyco-phosphoprotein with an approximate molecular weight of 105-120 kD. It is selectively expressed on the majority of hematopoietic stem\/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue. CD34 is a commonly used marker for identifying human hematopoietic stem\/progenitor cells. Based on different sensitivities, four groups of epitopes of CD34 have been described. CD34 mediates cell adhesion and lymphocytes homing through binding to L-selectin and E-selectin ligands.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: The 561 antibody recognizes a class III group epitope, which is resistant to sialidase\/glycolyprotease and chymopapain treatment.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Croockewit AJ, et al. 1998. Scand. J. Immunol. 47:82. Rosenzweig M, et al. 2001. J. Med. Primatol. 30:36.\u003cbr\u003e\nProduct Citations: Tuohinto K, et al. 2023. PLoS Pathog. 19:e1010753. PubMed Singh A, et al. 2020. Mol Oncol. 1.901388889. PubMed Zhang Y, et al. 2019. Nat Commun. 10:3667. PubMed Boulch M, et al. 2021. Sci Immunol. 6:. PubMed\u003cbr\u003e\nRRID: AB_2632631 (BioLegend Cat. No. 343617) AB_2632632 (BioLegend Cat. No. 343618)\u003cbr\u003e\nStructure: 105-120 kD single chain mucin-like glycoprotein\u003cbr\u003e\nDistribution: Hematopoietic stem\/progenitor cells, bone marrow stromal cells, endothelial cells, embryonic fibroblasts\u003cbr\u003e\nFunction: Cell adhesion\u003cbr\u003e\nLigand\/Receptor: L-selecin, E-selectin\u003cbr\u003e\nCell Type: Endothelial cells, Fibroblasts, Hematopoietic stem and progenitors\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 947\u003cbr\u003e\nUniProt: View information about CD34 on UniProt.org\u003cbr\u003e\nClone: 561\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gp105-120, My10, Mucosialin\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862444200105,"sku":"343618","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-343618","provider":"Iright","version":"1.0","type":"link"}