{"product_id":"biolegend-343808","title":"Biolegend, 343808, APC anti-human CD49c (integrin α3) Antibody, 100tests","description":"\u003cp\u003eCD49c is a 150 kD α integrin chain known as α3 integrin or VLA-3 α chain. It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c\/CD29, VLA-3) and is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding Kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human squamous cell carcinoma cell line SCC-9\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include: immunoprecipitation4, Western blotting5, and immunohistochemical staining of frozen tissue sections2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Pattaramalai S, et al. 1996. Exp. Cell. Res. 222:281.Skubitz AP, et al. 1996. Am. J. Pathol. 148:1445. (IHC)Skubitz AP, et al. 1998. FEBS Lett. 426:386.Calzada MJ, et al. 2004. Circ. Res. 94:462. (IP)Zhang X, et al. 2003. Surgery. 133:429. (WB)\u003cbr\u003e\nProduct Citations: Voit RA, et al. 2023. Nat Immunol. 24:69. PubMed Leduc A, et al. 2022. Genome Biol. 23:261. PubMed Bao EL, et al. 2020. Nature. 769:586. PubMed Shlamkovich T, et al. 2020. BMC Biology. 16(1):92. PubMed\u003cbr\u003e\nRRID: AB_10641282 (BioLegend Cat. No. 343808)\u003cbr\u003e\nStructure: 150 kD type I transmembrane glycoprotein, integrin family, associate with integrin β1(CD29)\u003cbr\u003e\nDistribution: Endothelial cells, epithelial cells, dermal fibroblast\u003cbr\u003e\nFunction: adhesion\u003cbr\u003e\nLigand\/Receptor: Kalinin, collagen, laminin-1, laminin-5 and entactin, fibronectin\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Fibroblasts\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and stromal Cell Molecules:the CD Markers. John Wiley \u0026amp; Sons Inc.\u003cbr\u003e\nGene ID: 3675\u003cbr\u003e\nUniProt: View information about CD49c on UniProt.org\u003cbr\u003e\nClone: ASC-1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI A002\u003cbr\u003e\nOther Names: α3 integrin, integrin α3 chain, VLA-3 α chain, VLA3a, ITGA3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862541783209,"sku":"343808","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-343808","provider":"Iright","version":"1.0","type":"link"}