{"product_id":"biolegend-344206","title":"Biolegend, 344206, APC anti-human CD143 (Angiotensin-converting enzyme) Antibody, 100tests","description":"\u003cp\u003eCD143 (ACE, kininase II, peptidyl dipeptidase 1, peptidase P, carboxycathepsin) is a 171 kD, type I, single chain transmembranal metallopeptidase, whose cofactor is zinc. Its main targets are angiotensin I and bradykinin, acting as a blood pressure regulator. CD143 is expressed in endothelial cells; varying amounts of CD143 have been reported in different epithelial cells. The activation of macrophages and histiocytes induces the expression of this molecule.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Pope C, et al. 2016. Circ Res . 119: 1204 - 1214. PubMed\u003cbr\u003e\nRRID: AB_11149487 (BioLegend Cat. No. 344206)\u003cbr\u003e\nStructure: Single chain, type I transmembranal zinc metallopeptidase, 170 kD.\u003cbr\u003e\nDistribution: Endothelial cells, some types of epithelial cells, activated macrophages and histiocytes.\u003cbr\u003e\nFunction: Regulates blood pressure by promoting vasoconstriction by the conversion of angiotensin I to angiotensin II and by the degradation of bradykinin, a vasodilator.\u003cbr\u003e\nLigand\/Receptor: Angiotensin I, bradykinin.\u003cbr\u003e\nBioactivity: Blood pressure regulator.\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Macrophages\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Nakamura T, et al. 2009. Int Heart J. 50:501. 2. Jayasooriya AP, et al. 2008. P. Natl. Acad. Sci. USA 105:6531. 3. Jokubaitis VJ, et al. 2008. Blood 111:4055. 4. Arndt PG, et al. 2006. J. Immunol. 177:7233. 5. Balyasnikova IV, et al. 2002. Biochem J. 362:585.\u003cbr\u003e\nGene ID: 1636\u003cbr\u003e\nUniProt: View information about CD143 on UniProt.org\u003cbr\u003e\nClone: 5-369\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ACE, kininase II, dipeptidyl dipeptidase 1, peptidase P, carboxycathepsin\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862423294121,"sku":"344206","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-344206","provider":"Iright","version":"1.0","type":"link"}