{"product_id":"biolegend-345204","title":"Biolegend, 345204, PE anti-human integrin β5 Antibody, 100tests","description":"\u003cp\u003eIntegrins are a family of transmembrane proteins. A total 17 integrin α chains and 8 β chains have been identified. The association of integrin α and β chains forms 25 integrin complexes which serve as extracellular matrix receptors and play important roles in cell adhesion and development. Integrin β5 is a 95 kD glycoprotein heterodimer with the αV subunit and is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. The αV\/β5 integrin complex binds to vitronectin.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Perna F, et al. 2017. Cancer Cell. 32:506. PubMed Zuidema A, et al. 2018. J Cell Sci. 131. PubMed Kawamoto E, et al. 2021. Biomedicines. 9:. PubMed\u003cbr\u003e\nRRID: AB_2129167 (BioLegend Cat. No. 345203)\u003cbr\u003e\nStructure: Integrin family, Ig superfamily, associates with αV subunit\u003cbr\u003e\nDistribution: Epithelial cells, endothelial cells, keratinocytes, osteoblastic cells\u003cbr\u003e\nFunction: Cell adhesion\u003cbr\u003e\nLigand\/Receptor: vitronectin\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Osteoclasts\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: 1. Kim JP. et al. 1994. J. Bio. Chem. 269:26926 2. Cheng SL. et al. 2000. J. Cell Biochem. 77:265 3. Aplin JD. et al. 1996. Mol. Hum. Reprod. 2:527\u003cbr\u003e\nGene ID: 3693\u003cbr\u003e\nUniProt: View information about Integrin beta 5 on UniProt.org\u003cbr\u003e\nClone: AST-3T\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: integrin b5, integrin beta 5, ITGB5\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862543683753,"sku":"345204","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-345204","provider":"Iright","version":"1.0","type":"link"}