{"product_id":"biolegend-346708","title":"Biolegend, 346708, APC anti-human NKp80 Antibody, 100tests","description":"\u003cp\u003eNKp80, also known as killer cell lectin-like receptor subfamily F, member 1 (KLRF1), is a type II transmembrane C-type lectin-like receptor. NKp80 is expressed on the cell surface of nearly all NK cells as a homodimer with approximately 80 kD molecular mass. It is also found on a subset of effector memory CD8 T cells and γ\/δ T cells. NKp80 induces NK-cell mediated cytotoxicity and cytokine production through interaction with its ligand, AICL (activation-induced C-type lectin), which is selectively expressed on myeloid cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant ectodomain of human NKp80\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Welte S, et al. 2006. Nat. Immunol. 7:1334. Kuttruff S, et al. 2009. Blood 113:358.\u003cbr\u003e\nProduct Citations: Orta-Resendiz A, et al. 2023. STAR Protoc. 102734:4. PubMed Francescone R, et al. 2020. Cancer Discovery. 11(2):446-479. PubMed\u003cbr\u003e\nRRID: AB_2044041 (BioLegend Cat. No. 346708)\u003cbr\u003e\nStructure: Type II transmembrane c-type lectin-like receptor, homodimer, 80 kD\u003cbr\u003e\nDistribution: NK cells, subset of CD8 T and γ\/δ T cells\u003cbr\u003e\nLigand\/Receptor: AICL (activation-induced C-type letcin)\u003cbr\u003e\nBioactivity: induce NK cell-mediated cytolysis and cytokine release\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology, Innate Immunity\u003cbr\u003e\nAntigen References: 1. Kuttruff S, et al. 2009. Blood 113:358 2. Vitale M, et al. 2001. Eur. J. Immunol. 31:233\u003cbr\u003e\nGene ID: 51348\u003cbr\u003e\nUniProt: View information about NKp80 on UniProt.org\u003cbr\u003e\nClone: 5D12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KLRF1, killer cell lectin-like receptor subfamily F, member 1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864163831977,"sku":"346708","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-346708","provider":"Iright","version":"1.0","type":"link"}