{"product_id":"biolegend-349107","title":"Biolegend, 349107, Pacific Blue™ anti-human CD235a (Glycophorin A) Antibody, 25μg","description":"\u003cp\u003eCD235a (Glycophorin A) is member of the glycophorin A family. It is a type I sialoglycoprotein with a molecular weight of 10 kD, present in the cell membrane as a homodimer. Glycophorin A is expressed by erythroid precursors and erythrocytes.  It carries the antigen determinants for the MNS blood groups and has been proposed to be an inhibitor of hemagglutination and hemolysis. Glycophorin A binds siglec 5, the erythrocyte binding antigen (EBA-175) of P. falciparum and some viruses, including influenza virus and hepatitis A virus.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Mason D, et al. Eds. 2002. Leucocyte Typing VII:White Cell Differentiation Antigens. Oxford University Press. (FC)\u003cbr\u003e\nProduct Citations: Borrelli MR, et al. 2020. Stem Cells Transl Med. 1.339583333. PubMed Zhang Q, et al. 2021. Nat Commun. 12:4592. PubMed Cai L, et al. 2018. Stem Cells Transl Med. 7:87. PubMed Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed Herland A, et al. 2020. Nat Biomed Eng. 421:4. PubMed Garrido-Martin EM, et al. 2020. J Immunother Cancer. 8:00. PubMed Phansalkar R, et al. 2021. Elife. 10:. PubMed Deleon NMD, et al. 2021. J Tissue Eng Regen Med. 15:1105. PubMed Krampitz G, et al. 2016. Proc Natl Acad Sci U S A. 113: 4464-4469. PubMed Sontheimer-Phelps A, et al. 2019. Cell Mol Gastroenterol Hepatol. 9:507. PubMed Chou DB, et al. 2020. Nat Biomed Eng. 0.440277778. PubMed\u003cbr\u003e\nRRID: AB_11219199 (BioLegend Cat. No. 349107) AB_11218988 (BioLegend Cat. No. 349108)\u003cbr\u003e\nStructure: Member of the glycophorin A family; type I protein with a molecular weight of 10 kD; present in the membrane as homodimer\u003cbr\u003e\nDistribution: Erythrocytes and erythroid precursors\u003cbr\u003e\nFunction: Possible inhibitor of hemagglutination and hemolysis; carries the antigen determinants for the MNS blood groups\u003cbr\u003e\nLigand\/Receptor: Siglec 5, erythrocyte binding antigen (EBA-175) of P. falciparum, receptor for the influenza virus, hepatitis A virus\u003cbr\u003e\nCell Type: Erythrocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Reid ME. 2009. Immunohematology 25:95. 2. Palacajornsuk P. 2006. Immunohematology 22:171. 3. Pasvol G. 2003. Trends Parasitol. 19:430. 4. Takakuwa Y. 2001. Curr. Opin. Hematol. 8:80.\u003cbr\u003e\nGene ID: 2993\u003cbr\u003e\nUniProt: View information about CD235a on UniProt.org\u003cbr\u003e\nClone: HI264\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VII 70312\u003cbr\u003e\nOther Names: PAS-2, Sialoglycoprotein alpha, MN sialoglycoprotein, Glycophorin A, GYPA\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866457165993,"sku":"349107","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-349107","provider":"Iright","version":"1.0","type":"link"}