{"product_id":"biolegend-352203","title":"Biolegend, 352203, PE anti-human CD207 (Langerin) Antibody, 25tests","description":"\u003cp\u003eCD207, also known as Langerin, is a 40 kD type II transmemberane cell glycoprotein which belongs to C-type lectin with mannose binding specificity. It is predominantly expressed on Langerhans cells and induces the formation of Birbeck granules, the Langerhans cell hallmark organelle. It is also found on several other subtypes of dendritic cells, such as dermal CD103-positive dendritic cells and splenic CD8-positive dendritic cells. Langerin is generally thought to be involved in antigen processing. Recently, it has been found that HIV captured by Langerin was internalized into Birbeck granule and degraded, which results in inhibition of HIV-1 infection and subsequent transmission.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Primary human Langerhans cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported application (for the relevant formats) includes: blocking the binding of HIV-1 to Langerhans cells1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Witte LD, et al. 2007. Nat. Med. 13:367. (Block)\u003cbr\u003e\nProduct Citations: Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed Cavrois M, et al. 2019. PLoS One. 14:e0221181. PubMed\u003cbr\u003e\nRRID: AB_10900993 (BioLegend Cat. No. 352203) AB_10897451 (BioLegend Cat. No. 352204)\u003cbr\u003e\nStructure: 40 kD glycoprotein\u003cbr\u003e\nDistribution: Langerhans cells, dermal CD103-positive dendritic cells, and splenic CD8-positive dendritic cells\u003cbr\u003e\nFunction: Binding and processing antigen; capturing, internalizing and degrading HIV\u003cbr\u003e\nLigand\/Receptor: Antigen containing mannose, N-acetyl glucosamine, and fucose\u003cbr\u003e\nCell Type: Dendritic cells, Langerhans cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Valladeau J, et al. 2000. Immunity 12:71. 2. Mc Dermott R, et al. 2002. Mol. Biol. Cell. 13:317. 3. Mizumoto N, et al. 2004. J. Clin. Invest. 113:701. 4. Witte LD, et al. 2007. Nat. Med. 13:367.\u003cbr\u003e\nGene ID: 50489\u003cbr\u003e\nUniProt: View information about CD207 on UniProt.org\u003cbr\u003e\nClone: 10E2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC4K\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860780306601,"sku":"352203","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-352203","provider":"Iright","version":"1.0","type":"link"}