{"product_id":"biolegend-352804","title":"Biolegend, 352804, PE anti-human CD126 (IL-6Rα) Antibody, 100tests","description":"\u003cp\u003eCD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain\/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human myeloma cell line U266\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Huang YW and Vitetta ES. 1993. Hybridoma 12:621.\u003cbr\u003e\nProduct Citations: Nunes-Santos CJ, et al. 2023. Nat Commun. 14:3708. PubMed Csomós I, et al. 2021. Int J Mol Sci. 22:. PubMed Zhang G, et al. 2020. Am J Transplant. 20:999. PubMed Ferreira R, et al. 2013. PLoS Genet. 9:1003444. PubMed Eriksson E, et al. 2016. Gene Ther. 10.1038\/gt.2016.80. PubMed Perrigue P, et al. 2015. Mol Cancer Res. 13:636. PubMed Eriksson E, et al. 2019. J Immunol. 202:787. PubMed Saga R, et al. 2019. Oncol Lett. 17:3555. PubMed Van Zeebroeck L, et al. 2021. Front Immunol. 12:655122. PubMed Alasady MJ, et al. 2021. PLoS One. 16:e0256238. PubMed Salameh JW, et al. 2022. Bioengineering (Basel). 9:. PubMed\u003cbr\u003e\nRRID: AB_10897103 (BioLegend Cat. No. 352803) AB_10900066 (BioLegend Cat. No. 352804)\u003cbr\u003e\nStructure: Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD\u003cbr\u003e\nDistribution: Plasma cells, T cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts\u003cbr\u003e\nFunction: Stimulates T cells, B cells, and hematopoietic precursor proliferation and differentiation\u003cbr\u003e\nInteraction: CD130, c-Src, STAT3, WWP1, WWP2\u003cbr\u003e\nLigand\/Receptor: IL-6\u003cbr\u003e\nCell Type: B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797. 2. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London. 3. Boulanger MJ, et al. 2003. Science 300:2101. 4. Gaillard JP, et al. 1993. Eur. J. Immunol. 23:820.\u003cbr\u003e\nGene ID: 3570\u003cbr\u003e\nUniProt: View information about CD126 on UniProt.org\u003cbr\u003e\nClone: UV4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-6R1, gp80, IL-6 receptor alpha, IL-6R\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864080863401,"sku":"352804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-352804","provider":"Iright","version":"1.0","type":"link"}