{"product_id":"biolegend-355305","title":"Biolegend, 355305, PE anti-human CD367 (CLEC4A) Antibody, 25tests","description":"\u003cp\u003eCD367 (CLEC4A), also known as lectin-like immunoreceptor (LLIR) and dendritic cell immunoreceptor (DCIR), is a type II transmembrane protein belonging to C-type lectin domain family, and was previously designated as CLECSF6. It contains one carbohydrate recognition domain in its C-terminal extracellular domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain.  CLEC4A is mainly expressed on monocytes, macrophages, dendritic cells, neutrophils, and B cells. It is also found on the surface of CD4 + T cells in rheumatoid arthritis (RA) patients. CLEC4A has been reported to function as a receptor for HIV, cross-present and cross-prime human CD8 + T cells. It might also function as a negative player by recruiting the SHP-1 or\/and SHP-2 phosphotase through its immunoreceptor tyrosine-based inhibitory motif (ITIM).\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Ectodomain of CLEC4A-human Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed\u003cbr\u003e\nRRID: AB_2561626 (BioLegend Cat. No. 355306)\u003cbr\u003e\nStructure: Type II transmembrane protein with single C-type lectin domain, contain immunoreceptor tyrosine-based inhibitory motif (ITIM)\u003cbr\u003e\nDistribution: Neturophils, monocytes, dendritic cells and B cells\u003cbr\u003e\nFunction: Receptor for HIV, cross-presentation and cross-priming of human CD8+ T cells, inhibit intracellular signaling\u003cbr\u003e\nCell Type: Neutrophils, Monocytes, Dendritic cells, B cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction, Costimulatory Molecules\u003cbr\u003e\nMolecular Family: CD Molecules, Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: 1. Lambert AA, et al. 2011. Blood 117:6589. 2. Klechevsky E, et al. 2010. Blood 116:1685. 3. Kanazawa N, et al. 2002. J. Invest Dermatol. 118:261. 4. Voehringer D, et al. 2001. J. Immunol. 167:4838.\u003cbr\u003e\nGene ID: 50856\u003cbr\u003e\nUniProt: View information about CLEC4A on UniProt.org\u003cbr\u003e\nClone: 9E8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: DCIR, LLIR, CLECSF6, CD367\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862509375657,"sku":"355305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-355305","provider":"Iright","version":"1.0","type":"link"}