{"product_id":"biolegend-357904","title":"Biolegend, 357904, PE anti-human CXCL9 (MIG) Antibody, 100tests","description":"\u003cp\u003eChemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), is a small cytokine belonging to the non-ELR (lacking a Glu-Leu-Arg motif in the N-terminal region) motif CXC chemokines. CXCL9 shares the CXCR3 with CXCL10 and CXCL11, and these ligands differ in their receptor-binding and activating properties; CXCL11 is more potent than CXCL10 and CXCL10 is more potent than CXCL9. Some studies have revealed that these ligands have redundant functions in vivo ; other studies have demonstrated that the three CXCR3 ligands can collaborate and even compete with each other.  CXCL9 is mainly produced by activated macrophages and some cancer cells. Functioning as a chemoattractant, CXCL9 attracts CXCR3-expressing cells (such as a subset of circulating T cells, B cells, and natural killer cells) into inflammatory sites. Like other chemokines, CXCL9 is also able to elicit intracellular calcium flux and activate PI3K and MAPK. It participates in multiple immune and inflammatory responses by affecting cell growth, movement, or activation.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human CXCL9.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Aru B, et al. 2023. Balkan Med J. 40:117. PubMed de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed\u003cbr\u003e\nRRID: AB_2562005 (BioLegend Cat. No. 357903) AB_2562009 (BioLegend Cat. No. 357904)\u003cbr\u003e\nStructure: A member of the alpha subfamily of inflammatory chemokines.\u003cbr\u003e\nDistribution: Activated macrophages and some cancer cells.\u003cbr\u003e\nFunction: Attracts CXCR3-expressing cells, such as a subset of circulating T cells, B cells, and natural killer cells.\u003cbr\u003e\nLigand\/Receptor: CXCR3\u003cbr\u003e\nCell Type: B cells, Macrophages\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Groom JR, et al. 2012. Immunity 37:1091. 2. Loetscher P, et al. 2001. J. Biol. Chem. 276:2986. 3. Jones D, et al. 2000. Blood 95:627. 4. Liao F, et al. 1995. J. Exp. Med. 182:1301.\u003cbr\u003e\nGene ID: 4283\u003cbr\u003e\nUniProt: View information about CXCL9 on UniProt.org\u003cbr\u003e\nClone: J1015E10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MIG-1, MIG\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866110939305,"sku":"357904","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-357904","provider":"Iright","version":"1.0","type":"link"}