{"product_id":"biolegend-358402","title":"Biolegend, 358402, Purified anti-human CD120b Antibody, 100μg","description":"\u003cp\u003eCD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2 that possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial CD120b recombinant protein expressed in 293E cells (22-211aa).\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Minshawi F, et al. 2019. Sci Rep. 0.509027778. PubMed De Maeyer RPH, et al. 2020. Nat Immunol. 21:615. PubMed\u003cbr\u003e\nRRID: AB_2562150 (BioLegend Cat. No. 358402)\u003cbr\u003e\nStructure: 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI\u003cbr\u003e\nDistribution: Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes\u003cbr\u003e\nFunction: When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 that possess ubiquitin ligase activity; cysteine rich extracellular region\u003cbr\u003e\nInteraction: Interacts with TTRAP and TRAF2\u003cbr\u003e\nLigand\/Receptor: TNF-α and TNF-β (LT-α)\u003cbr\u003e\nCell Type: Granulocytes, Lymphocytes, Monocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Andrews JS, et al. 1990. J. Immunol. 144:2582. 2. Nophar Y, et al. 1990. EMBO J. 9:3269. 3. Kohno T, et al. 1990. Proc. Natl. Acad. Sci. USA 87:8331. 4. Tartaglia LA, et al. 1991. Proc. Natl. Acad. Sci. USA 88:9292. 5. Hijdra D, et al. 2012. J. Inflamm. (Lond). 9:38. 6. Chen X, et al. 2013. J. Immunol. 190:1076.\u003cbr\u003e\nGene ID: 7133\u003cbr\u003e\nUniProt: View information about CD120b on UniProt.org\u003cbr\u003e\nClone: 3G7A02\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864372826281,"sku":"358402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-358402","provider":"Iright","version":"1.0","type":"link"}