{"product_id":"biolegend-360610","title":"Biolegend, 360610, APC anti-human CD198 (CCR8) Antibody, 100tests","description":"\u003cp\u003eCCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CCR8-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2820017 (BioLegend Cat. No. 360609) AB_2820018 (BioLegend Cat. No. 360610)\u003cbr\u003e\nStructure: Seven hydrophobic transmembrane domains\u003cbr\u003e\nDistribution: Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons\u003cbr\u003e\nFunction: Regulation of monocyte chemotaxis and thymic cell apoptosis\u003cbr\u003e\nLigand\/Receptor: CCL1, CCL18\u003cbr\u003e\nCell Type: Dendritic cells, Eosinophils, Langerhans cells, Macrophages, Neurons, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Tiffany HL, et al. 1997. J. Exp. Med. 186:165. 2. Goya I, et al. 1998. J. Immunol. 160:1975. 3. Lee S, et al. 2000. J. Virol. 74:6946. 4. Chensue SW, et al. 2001. J. Exp. Med. 193:573. 5. Qu C, et al. 2004. J. Exp. Med. 200:1231. 6. Isolam SA, et al. 2003. J. Exp. Med. 210:1889.\u003cbr\u003e\nGene ID: 1237\u003cbr\u003e\nUniProt: View information about CD198 on UniProt.org\u003cbr\u003e\nClone: L263G8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CC-CKR-8,C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?\u003cbr\u003e\nA: Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866119295145,"sku":"360610","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-360610","provider":"Iright","version":"1.0","type":"link"}