{"product_id":"biolegend-364305","title":"Biolegend, 364305, Alexa Fluor® 647 anti-human CD163 Recombinant Antibody, 25tests","description":"\u003cp\u003eCD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI\/61, M130, RM3\/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)\/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. For immunohistochemistry, a concentration range of 5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2922575 (BioLegend Cat. No. 364305) AB_2922575 (BioLegend Cat. No. 364306)\u003cbr\u003e\nStructure: 134 kD (non-reduced)\/155 kD (reduced) glycoprotein, scavenger receptor superfamily\u003cbr\u003e\nDistribution: Monocytes, macrophages, Kuffer cells, subset of dendritic cells, subset of hematopoietic stem\/progenitor cells\u003cbr\u003e\nFunction: Clearance of haptoglobin-hemoglobin complex, regulation of cytokine production by macrophages\u003cbr\u003e\nLigand\/Receptor: Haptoglobin-hemoglobin complex, TWEAK\u003cbr\u003e\nAntigen References: Roth J, et al. 1994. Transolantation. 57:127 Van den Heuvel MM, et al.1999. J Leukoc Biol. 66:858 Sulahian TH, et al. 2000. Cytokines. 12:1312 Fabriek BO, et al. 2007. J Neuroimmunol. 187:179\u003cbr\u003e\nGene ID: 9332\u003cbr\u003e\nUniProt: View information about CD163 on UniProt.org\u003cbr\u003e\nClone: QA19A16\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GHI\/61, M130, RM3\/1, p155, Hemoglobin\/Haptoglobin Complex Receptor, macrophage-associated antigen, ED2(rat)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866186797225,"sku":"364305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-364305","provider":"Iright","version":"1.0","type":"link"}