{"product_id":"biolegend-367716","title":"Biolegend, 367716, APC anti-human KLRG1 (MAFA) Antibody, 100tests","description":"\u003cp\u003eKiller cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). KLRG1 is expressed by subsets of NK, effector and memory T cells. KLRG1 inhibits cell activation and proliferation, and is a marker of T cell senescence. Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human KLRG1-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Gatla H, et al. 2022. Front Med Technol. 4:850565. PubMed Herter JM, et al. 2022. Strahlenther Onkol. Online ahead of print. PubMed Sureshchandra S, et al. 2022. Cell Rep. 39:110938. PubMed\u003cbr\u003e\nRRID: AB_2572160 (BioLegend Cat. No. 367715) AB_2572161 (BioLegend Cat. No. 367716)\u003cbr\u003e\nStructure: Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.\u003cbr\u003e\nDistribution: Subsets of NK, effector and memory T cells.\u003cbr\u003e\nFunction: Inhibits cell activation and proliferation, marker of T cell senescence.\u003cbr\u003e\nInteraction: AKT\u003cbr\u003e\nLigand\/Receptor: E-, N-, and R- cadherins\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nAntigen References: 1. Shi L, et al. 2014. J. Immunol. 192:649.\u003cbr\u003e\nGene ID: 10219\u003cbr\u003e\nUniProt: View information about KLRG1 on UniProt.org\u003cbr\u003e\nClone: SA231A2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866287034537,"sku":"367716","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-367716","provider":"Iright","version":"1.0","type":"link"}