{"product_id":"biolegend-367726","title":"Biolegend, 367726, KIRAVIA Blue 520™ anti-human KLRG1 (MAFA) Antibody, 100tests","description":"\u003cp\u003eKiller cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). KLRG1 is expressed by subsets of NK, effector and memory T cells. KLRG1 inhibits cell activation and proliferation, and is a marker of T cell senescence. Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human KLRG1-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm. KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.Sony and the Sony logo are registered trademarks of Sony Corporation.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nRRID: AB_2890800 (BioLegend Cat. No. 367725) AB_2890800 (BioLegend Cat. No. 367726)\u003cbr\u003e\nStructure: Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.\u003cbr\u003e\nDistribution: Subsets of NK, effector and memory T cells.\u003cbr\u003e\nFunction: Inhibits cell activation and proliferation, marker of T cell senescence.\u003cbr\u003e\nInteraction: AKT\u003cbr\u003e\nLigand\/Receptor: E-, N-, and R- cadherins\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nAntigen References: 1. Shi L, et al. 2014. J. Immunol. 192:649.\u003cbr\u003e\nGene ID: 10219\u003cbr\u003e\nUniProt: View information about KLRG1 on UniProt.org\u003cbr\u003e\nClone: SA231A2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866286641321,"sku":"367726","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-367726","provider":"Iright","version":"1.0","type":"link"}