{"product_id":"biolegend-368606","title":"Biolegend, 368606, APC anti-human KLRG1 (MAFA) Antibody, 100tests","description":"\u003cp\u003eKiller cell lectin-like receptor subfamily G member (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibitory motif (ITIM). KLRG1 is expressed by subsets of natural killer cells (NKs) and effector and memory T cells. It inhibits cell activation and proliferation and is also a marker of T cell senescence. The binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of AKT and increases the expression of cell cycle inhibitors.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human KLRG1-transfected cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Sun W, et al. 2023. Nature. 614:309. PubMed Kobayashi Y, et al. 2020. Int J Oncol. 999:56. PubMed Brudno JN, et al. 2020. Nat Med. 270:26. PubMed\u003cbr\u003e\nRRID: AB_2571924 (BioLegend Cat. No. 368605) AB_2571925 (BioLegend Cat. No. 368606)\u003cbr\u003e\nStructure: Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.\u003cbr\u003e\nDistribution: Subsets of natural killer cells, effector and memory T cells.\u003cbr\u003e\nFunction: Inhibits cell activation and proliferation\u003cbr\u003e\nInteraction: AKT.\u003cbr\u003e\nLigand\/Receptor: E-, N-, R- cadherins.\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nAntigen References: 1. Shi L, et al. 2014. J. Immunol. 192:649.\u003cbr\u003e\nGene ID: 10219\u003cbr\u003e\nUniProt: View information about KLRG1 on UniProt.org\u003cbr\u003e\nClone: 14C2A07\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864337240233,"sku":"368606","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-368606","provider":"Iright","version":"1.0","type":"link"}