{"product_id":"biolegend-368713","title":"Biolegend, 368713, Alexa Fluor® 647 anti-human Cadherin 11 Antibody, 25μg","description":"\u003cp\u003eCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 11 is a type I transmembrane glycoprotein. It is a type II (atypical) cadherin, based on its lack of a HAV cell adhesion recognition sequence that is specific to type I cadherins. The expression of this particular cadherin in osteoblastic cell lines along with its upregulation during differentiation suggests a specific function in bone development and maintenance. This cadherin is also expressed in some cancer cells.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant protein containing the extracellular cadherin domain 1 of Cadherin 11 fused to maltose binding protein.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation.\u003cbr\u003e\nRRID: AB_2721403 (BioLegend Cat. No. 368713)\u003cbr\u003e\nStructure: Type I single pass transmembrane glycoprotein.\u003cbr\u003e\nDistribution: Osteoblasts, neuroblasts, and some cancer cells.\u003cbr\u003e\nFunction: Cell adhesion.\u003cbr\u003e\nInteraction: Cadherin 2 (CDH2).\u003cbr\u003e\nLigand\/Receptor: Calcium.\u003cbr\u003e\nCell Type: Osteoclasts\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: 1. Wheelock MJ, Johnson KR. 2003. Annu. Rev. Cell Dev. Biol. 19:207-35. 2. Christofori G, et al. 2003. EMBO. J. 22:2318. 3. Okazaki M, et al. 1994. J. Biol. Chem. 269:12092.\u003cbr\u003e\nGene ID: 1009\u003cbr\u003e\nUniProt: View information about Cadherin 11 on UniProt.org\u003cbr\u003e\nClone: 16G5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: OSF-4, Osteoblast cadherin, OB-cadherin, CDH11, CDHOB, CAD11\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860820152489,"sku":"368713","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-368713","provider":"Iright","version":"1.0","type":"link"}