{"product_id":"biolegend-371702","title":"Biolegend, 371702, Purified anti-human CLEC5A Antibody, 100μg","description":"\u003cp\u003eCLEC5A\/MDL1 is a 40 kD transmembrane glycoprotein belonging to the C-type lectin superfamily; alternative splice variants have been described but their full-length sequence has not been determined. CLEC5A mediates inflammatory responses during autoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses. It also positively regulates osteoclastogenesis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial recombinant protein (28 — 188 a.a.) expressed in 293E cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2616916 (BioLegend Cat. No. 371702)\u003cbr\u003e\nStructure: Approximately 21 kD C-type lectin domain-containing glyocoprotein.\u003cbr\u003e\nDistribution: Expressed on immature myeloid cells, monocytes, macrophages, dendritic cells, neutrophils, NK cells, and osteocytes.\u003cbr\u003e\nFunction: Cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response.\u003cbr\u003e\nInteraction: DAP12, TYROBP\u003cbr\u003e\nLigand\/Receptor: Dengue Virus Envelope Proteins\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes, Neutrophils, NK cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nAntigen References: 1. Chen DY, et al. 2014. PLoS One e86105. 2. Wu MF, et al. 2013. Blood 121:95. 3. Yang YL, et al. 2012. J. Biomed. Biotechnol. 2012:398628. 4. Watson AA, et al. 2011. J. Biol. Chem. 286(27):24208.\u003cbr\u003e\nGene ID: 23601\u003cbr\u003e\nUniProt: View information about CLEC5A on UniProt.org\u003cbr\u003e\nClone: 14H4-1-2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MDL1, MDL-1, CLECSFS\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864350511273,"sku":"371702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-371702","provider":"Iright","version":"1.0","type":"link"}