{"product_id":"biolegend-371708","title":"Biolegend, 371708, PE\/Dazzle™ 594 anti-human CLEC5A Antibody, 100tests","description":"\u003cp\u003eCLEC5A\/MDL1 is a 40 kD transmembrane glycoprotein belonging to the C-type lectin superfamily; alternative splice variants have been described but their full-length sequence has not been determined. CLEC5A mediates inflammatory responses during autoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses. It also positively regulates osteoclastogenesis.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial recombinant protein (28 — 188 a.a.) expressed in 293E cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2922587 (BioLegend Cat. No. 371707) AB_2922587 (BioLegend Cat. No. 371708)\u003cbr\u003e\nStructure: Approximately 21 kD C-type lectin domain-containing glyocoprotein.\u003cbr\u003e\nDistribution: Expressed on immature myeloid cells, monocytes, macrophages, dendritic cells, neutrophils, NK cells, and osteocytes.\u003cbr\u003e\nFunction: Cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response.\u003cbr\u003e\nInteraction: DAP12, TYROBP\u003cbr\u003e\nLigand\/Receptor: Dengue Virus Envelope Proteins\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes, Neutrophils, NK cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nAntigen References: 1. Chen DY, et al. 2014. PLoS One e86105. 2. Wu MF, et al. 2013. Blood 121:95. 3. Yang YL, et al. 2012. J. Biomed. Biotechnol. 2012:398628. 4. Watson AA, et al. 2011. J. Biol. Chem. 286(27):24208.\u003cbr\u003e\nGene ID: 23601\u003cbr\u003e\nUniProt: View information about CLEC5A on UniProt.org\u003cbr\u003e\nClone: 14H4-1-2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MDL1, MDL-1, CLECSFS\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864350380201,"sku":"371708","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-371708","provider":"Iright","version":"1.0","type":"link"}