{"product_id":"biolegend-372612","title":"Biolegend, 372612, FITC anti-human XCR1 Antibody, 100tests","description":"\u003cp\u003eXCR1, also known as GPR5 or CCXCR1, is a 38 kD G-protein coupled, seven transmembrane receptor. It is the only member of the \"C\" chemokine receptor family and mediates chemotaxis of XCL1 and XCL2 (lymphotactin-1 and -2). XCR1 is expressed on a subset of CD141 + conventional dendritic cells. XCR1 is also involved in the migration and proliferation of some cancer cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human XCR1-transfected cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nProduct Citations: Findlay EG, et al. 2019. Oncoimmunology. 8:1608106. PubMed Asokan M, et al. 2020. Proc Natl Acad Sci U S A. 117:18754. PubMed Mulder K, et al. 2021. Immunity. 54(8):1883-1900.e5. PubMed\u003cbr\u003e\nRRID: AB_2715830 (BioLegend Cat. No. 372611) AB_2715831 (BioLegend Cat. No. 372612)\u003cbr\u003e\nStructure: Only member of the \"C\" chemokine receptor family, seven transmembrane receptor, coupled to G protein, 38 kD.\u003cbr\u003e\nDistribution: Subset of CD141+ conventional dendritic cells.\u003cbr\u003e\nFunction: Mediates chemotaxis to XCL1.\u003cbr\u003e\nLigand\/Receptor: XCL1 and XCL2.\u003cbr\u003e\nCell Type: Dendritic cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Carpentier S, et al. 2016. J. Immunol. Methods 432:35. 2. Hartung E, et al. 2015. J. Immunol. 194:1069. 3. Wang T, et al. 2015. Biochem. Biophys. Res. Commun. 464:635. 4. Crozat K, et al. 2011. J. Immunol. 187:4411.\u003cbr\u003e\nGene ID: 2829\u003cbr\u003e\nUniProt: View information about XCR1 on UniProt.org\u003cbr\u003e\nClone: S15046E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GPR5, CCXCR1, mXCR1, Lymphotactin receptor, SCM1 receptor, XC chemokine receptor 1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866216681641,"sku":"372612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-372612","provider":"Iright","version":"1.0","type":"link"}