{"product_id":"biolegend-373106","title":"Biolegend, 373106, FITC anti-human CD312 (EMR2) Antibody, 100tests","description":"\u003cp\u003eCD312, also known as Epidermal growth factor module-containing mucin-like receptor 2 (EMR2), is a 90 kD type I protein, a member of the Epidermal Growth Factor-seven transmembrane (EGF-TM7) family. Its extracellular region consists of five tandem EGF-like adhesion domains and a mucin-like stalk domain containing a G-protein proteolytic site, while the C-terminal region consists of a seven-pass transmembrane domain. CD312 is expressed by myeloid cells, dendritic cells, and activated lymphocytes. CD312 contributes to the interaction of macrophages, dendritic cells and activated T cells with B cells; it is involved in neutrophil chemotaxis, degranulation and adhesion, and release of inflammatory cytokines by macrophages. The ligands of CD312 are the glycosaminoglycans (GAG) chondroitin sulphate, and dermatan sulphate.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant protein fragment containing the first extracellular region of human EMR2 (24-540 a.a.).\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nRRID: AB_2922589 (BioLegend Cat. No. 373105) AB_2922589 (BioLegend Cat. No. 373106)\u003cbr\u003e\nStructure: Member of the Epidermal Growth Factor-seven transmembrane (EGF-TM7) family, type I protein, its extracellular region consists of five tandem EGF-like adhesion domains and a mucin-like stalk domain containing a G-protein proteolytic site; the C-terminal re\u003cbr\u003e\nDistribution: Expressed by myeloid cells, dendritic cells, and activated lymphocytes.\u003cbr\u003e\nFunction: Involved in neutrophil chemotaxis, degranulation and adhesion. Promotes the release of inflammatory cytokines by macrophages. Contributes in the interaction of macrophages, dendritic cells and activated T cells with B cells.\u003cbr\u003e\nLigand\/Receptor: Chondroitin sulphate, dermatan sulphate.\u003cbr\u003e\nCell Type: Dendritic cells, Lymphocytes, Neutrophils\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Boyden SE, et al. 2016. N. Engl. J. Med. 374:656. 2. Lewis SM, et al. 2015. Clin. Exp. Immunol. 182:184. 3. Huang YS, et al. 2012. Mol. Cell Biol. 32:1408. 4. Rutkowski MJ, et al. 2011. J. Neurooncol. 105:165. 5. van Eijk M, et al. 2010. Immunol. Lett. 129:64.\u003cbr\u003e\nGene ID: 30817\u003cbr\u003e\nUniProt: View information about CD312 on UniProt.org\u003cbr\u003e\nClone: W15101A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Epidermal growth factor module-containing mucin-like receptor 2, EMR2, AGRE2, ADGRE2\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866298273961,"sku":"373106","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-373106","provider":"Iright","version":"1.0","type":"link"}