{"product_id":"biolegend-373309","title":"Biolegend, 373309, Biotin anti-human HLA-C Antibody, 100μg","description":"\u003cp\u003eHLA-C belongs to the HLA class I heavy chain paralogues. MHC class I heavy chains associate with β2-microglobulin and are expressed on nearly all nucleated cells. MHC class I molecules are involved in the presentation of antigens to CD8+ T cells and thereby play an important role in cell-mediated immune responses and immune surveillance. Detailed characterization of the DT-9 clone indicates that it cross-reacts with HLA-E and certain HLA-A and HLA-B allotypes.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified tamarin MHC class I molecules, corresponding to human HLA-C\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Corrah et al. 2011. J. Virol. 85: 3367. Apps et al. 2013. Science. 340:87. Braud et al. 1998. Curr. Biol. 8:1. Thomas R, et al. 2009. Nat. Genet. 41:1290. (HLA-A\/B allotype cross-reactivity)\u003cbr\u003e\nProduct Citations: Hofman T, et al. 2024. J Immunother Cancer. :12. PubMed\u003cbr\u003e\nRRID: AB_2894583 (BioLegend Cat. No. 373309)\u003cbr\u003e\nStructure: Ig superfamily\u003cbr\u003e\nDistribution: Nearly all cells\u003cbr\u003e\nFunction: Antigen peptide presentation\u003cbr\u003e\nLigand\/Receptor: TCR, CD8\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nGene ID: 3107\u003cbr\u003e\nUniProt: View information about HLA-C on UniProt.org\u003cbr\u003e\nClone: DT-9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: HLAC, MHC Class I Antigen C\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863022915753,"sku":"373309","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-373309","provider":"Iright","version":"1.0","type":"link"}