{"product_id":"biolegend-373802","title":"Biolegend, 373802, Purified anti-human LGR5 (GPR49) Antibody, 100μg","description":"\u003cp\u003eLGR5, also known as GPR49, is a 100 KD protein. It is a member of GPCR class A orphan receptor proteins which binds R-spondin and does not activate through heterotrimeric G protein like other GPCR. It triggers the Wnt signaling pathway downstream. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human LGR5 transfectant cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Neuwelt AJ, et al. 2020. J Immunother Cancer. :8. PubMed Anchan A, et al. 2020. Int J Mol Sci. :21. PubMed Li Z, et al. 2020. J Clin Lab Anal. 34:e23155. PubMed\u003cbr\u003e\nRRID: AB_2686986 (BioLegend Cat. No. 373802)\u003cbr\u003e\nStructure: G-protein coupled receptor (GPCR) superfamily\u003cbr\u003e\nDistribution: Muscle, placenta, spinal cord, brain and particularly as a biomarker of adult stem cells in certain tissues.\u003cbr\u003e\nFunction: Triggers Wnt signaling pathway.\u003cbr\u003e\nInteraction: Wnt pathway\u003cbr\u003e\nLigand\/Receptor: R-spondins (RSpo 1,2,3, and 4)\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nAntigen References: 1. Hsu Sy, et al. 1998. Mol. Endocrinol. 12:1830. 2. Barker N, et al. 2007. Nature. 449:1003. 3. Morita H, et al. 2004. Mol. Cell. Biol. 24(22):9736. 4. Arioka Y, et al. 2017. Stem Cell Res. 20:1. 5. Wang B, et al. 2016. Plos. One. 11:e0168904. 6. Garcia MI, et al. 2009. Dev. Biol. 331:58.\u003cbr\u003e\nGene ID: 8549\u003cbr\u003e\nUniProt: View information about LGR5 on UniProt.org\u003cbr\u003e\nClone: SA222C5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: G-Protein coupled receptor 49 (GPR49), G-Protein coupled receptor 67 (GPR67), FEX, HG38\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866286477481,"sku":"373802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-373802","provider":"Iright","version":"1.0","type":"link"}