{"product_id":"biolegend-374006","title":"Biolegend, 374006, Spark YG™ 570 anti-human CD309 (VEGFR2) Antibody, 100μg","description":"\u003cp\u003eCD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1\/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Human VEGFR2-Fc Chimera\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Spark YG™ 570 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Spark YG™ 570 has a maximum excitation of 555 nm and a maximum emission of 570 nm.\u003cbr\u003e\nExcitation Laser: Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2860956 (BioLegend Cat. No. 374005) AB_2860957 (BioLegend Cat. No. 374006)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1\/PDGF receptor family\u003cbr\u003e\nDistribution: Endothelial cells, embryonic tissues\u003cbr\u003e\nFunction: VEGFR2 regulates angiogenesis as well as vascular development and permeability\u003cbr\u003e\nInteraction: VEGF-A, SHC2, NPR1, NCK1\u003cbr\u003e\nLigand\/Receptor: VEGF-A, VEGF-C, and VEGF-D splice isoforms\u003cbr\u003e\nCell Type: Endothelial cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. DiSalvo J, et al. 1995. J. Biol. Chem. 270:7717. 2. McColl BK, et al. 2003. J. Exp. Med. 198:863. 3. Albuquerque RJ, et al. 2009. Nat. Med. 15:1023. 4. Guangqi E, et al. 2012. J. Biol. Chem. 287:3029. 5. Koch S, and Claesson-Welsh 2012. Cold Spring Harb Perspect Med 2:a006502. 6. Munaut C, et al. 2012. Plos One 7:e33475. 7. Wehland M, et al. 2013. Int. J. Mol. Sci. 14:9338.\u003cbr\u003e\nGene ID: 3791\u003cbr\u003e\nUniProt: View information about CD309 on UniProt.org\u003cbr\u003e\nClone: A16085I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: VEGFR2, KDR\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864395894953,"sku":"374006","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-374006","provider":"Iright","version":"1.0","type":"link"}